Yulia Kushnareva

[This is an article/biographic entry for a future reference book "Who's Who in Aging Research"]

Yulia Kushnareva, Ph. D. - a scientist, notable for the following interesting research findings and publications relevant to the problems of human health, aging and longevity:

Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival
Journal of Biological Chemistry. 2005, Dec 9; 280(49): 40398-401. PMID 16207717

Excitotoxic injury to mitochondria isolated from cultured neurons
Journal of Biological Chemistry. 2005, Aug 12; 280(32): 28894-902. PMID 15932874

OPA1 expression in the normal rat retina and optic nerve
The Journal of Comparative Neurology. 2005, Jul 18; 488(1): 1-10. PMID 15912498

Mitochondrial metabolism of reactive oxygen species
Biochemistry (Moscow). 2005, Feb; 70(2): 200-14. Review. PMID 15807660

Cellular and subcellular calcium accumulation during glutamate-induced injury in cerebellar granule neurons
Journal of Neurochemistry. 2005, Mar; 92(5): 1081-90. PMID 15715659

Inhibition of mitochondrial Na+-Ca2+ exchanger increases mitochondrial metabolism and potentiates glucose-stimulated insulin secretion in rat pancreatic islets
Diabetes. 2003, Apr; 52(4): 965-73. PMID 12663468

Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state
Biochemical Journal. 2002, Dec 1; 368(Pt 2): 545-53. PMID 12180906, http://www.biochemj.org/bj/368/0545/3680545.pdf ; http://www.biochemj.org/bj/368/bj3680545.htm

Mitochondrial precursor signal peptide induces a unique permeability transition and release of cytochrome c from liver and brain mitochondria
Archives of Biochemistry and Biophysics. 2001, Feb 15; 386(2): 251-60. PMID 11368349

Apoptosis-related activities measured with isolated mitochondria and digitonin-permeabilized cells
Methods in Enzymology (Apoptosis). 2000; 322: 222-34. PMID 10914020

Prooxidants open both the mitochondrial permeability transition pore and a low-conductance channel in the inner mitochondrial membrane
Arch Biochem Biophys. 2000, Apr 15; 376(2): 377-88. PMID 10775426

Signal presequences increase mitochondrial permeability and open the multiple conductance channel
Arch Biochem Biophys. 1999, Jun 1; 366(1): 107-15. PMID 10334870

The role of low (< or = 1 mM) phosphate concentrations in regulation of mitochondrial permeability: modulation of matrix free Ca2+ concentration
Arch Biochem Biophys. 1999, Mar 1; 363(1): 155-62. PMID 10049510

Evolution, mutations, and human longevity: European royal and noble families
Human Biology. 1998, Aug; 70(4): 799-804. PMID 9686488

Regularities in the inheritance of human life expectancy: contribution of paternal and maternal longevity on life span of offspring
Doklady Akademii Nauk, 1998, 360(2), 281-3, PMID: 9719896
http://library.iem.ac.ru/dan/1998/2-36098.html

Evolution theory, mutations, and human life span
Doklady Akademii Nauk, 1998, 359(3), 426-7, PMID: 9608918
http://library.iem.ac.ru/dan/1998/3-35998.html

Mutation load and human longevity
Mutation Research. 1997, Jun 9; 377(1): 61-2. PMID 9219579

Effect of butylhydroxytoluene and related compounds on permeability of the inner mitochondrial membrane
Arch Biochem Biophys. 1997, Jun 1; 342(1): 143-56. PMID 9185623

Ca(2+)-loading modulates potencies of cyclosporin A, Mg2+ and ADP to recouple permeabilized rat liver mitochondria
Biochem Mol Biol Int. 1994, Sep; 34(2): 367-73. PMID 7849648

Effects of the membrane potential upon the Ca(2+)- and cumene hydroperoxide-induced permeabilization of the inner mitochondrial membrane
FEBS Lett. 1991, Dec 16; 295(1-3): 77-80. PMID 1722466

Mechanism accounting for the induction of nonspecific permeability of the inner mitochondrial membrane by hydroperoxides
Biochim Biophys Acta. 1991, Jun 17; 1058(2): 242-8. PMID 2049374

Effect of ADP/ATP antiporter conformational state on the suppression of the nonspecific permeability of the inner mitochondrial membrane by cyclosporine A
FEBS Lett. 1990, Dec 17; 277(1-2): 123-6. PMID 2269342

Effect of cyclosporine A and oligomycin on non-specific permeability of the inner mitochondrial membrane
FEBS Lett. 1990, Sep 17; 270(1-2): 108-10. PMID 1699789
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Invited Lecture at Buck Institute for Age Research, California, USA:

-- "Bioenergetic Dysfunction Associated with Mitochondrial Fission in OPA1 Knockdown Cells"
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Preprints and working papers:

Parental Predictors of Human Longevity
Longevity Report, 1997, 11( 60), ISSN: 0964-5659

Comparison of Maternal and Paternal Effects on Human Longevity
Longevity Report, 1997, 11( 60), ISSN: 0964-5659

The Mechanism of Human Longevity
Longevity Report, 1996, 10(57), ISSN: 0964-5659

Specific Decrease in Longevity of Daughters Conceived by Old Fathers
Longevity Report, 1996, 10( 56), ISSN: 0964-5659

The revival of longevity genetics
Longevity Report, 1996, 10(55), 3-4. ISSN: 0964-5659

Determinants of human longevity: parental age at reproduction and offspring longevity
Longevity Report, 1996, 10(54), 7-15. ISSN: 0964-5659

Human Longevity: Past, Present and Future
Longevity Report, 1995, 9(52), p.3-4, ISSN: 0964-5659
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Some notable abstracts:

Prooxidants open two different pores in the inner mitochondrial membrane
The 2nd Albany Conference on Frontiers of Mitochondrial Research, September 24-27, 1998, Rensselaerville, NY, USA

Parental age at reproduction as a predictor of human longevity
In: 16th Congress of the IAG [International Association of Gerontology], August 19-23, 1997. Book of Abstracts. Adelaide, 1997, pp.461-462.

Testing the evolutionary theory of longevity
In: 16th Congress of the IAG [International Association of Gerontology], August 19-23, 1997. Book of Abstracts. Adelaide, 550.
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Yulia Kushnareva is a recipient of a prestigious grant award from the International Science Foundation
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CV of Dr. Yulia Kushnareva can be found at:

http://longevity-science.org/CV-Yulia-Kushnareva.pdf
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