Saturday, February 14, 2015

Predictors of Exceptional Longevity

Dear Colleagues,

We are pleased to alert you that our new peer-reviewed study on Predictors of Exceptional Longevity is now publicly available at PubMed Central® (PMC) - a free full-text archive of biomedical and life sciences journal literature at the U.S. National Institutes of Health's National Library of Medicine (NIH/NLM):

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318523/

Comments and suggestions are most welcome!

Kind regards,

-- Leonid and Natalia
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-- Leonid Gavrilov, Ph.D., GSA Fellow
-- Natalia Gavrilova, Ph.D., GSA Fellow
Center on Aging, NORC at the University of Chicago
Website: http://longevity-science.org/

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Predictors of Exceptional Longevity:
Effects of Early-Life Childhood Conditions, Mid-Life Environment and Parental Characteristics
Gavrilov L.A., Gavrilova N.S.
In: 2014 Living to 100 Monograph [ available in PMC 2015 Feb 5 ].
The Society of Actuaries, 2014, 18 pages

Abstract:

Knowledge of strong predictors of mortality and longevity is very important for actuarial science and practice. Earlier studies found that parental characteristics as well as early-life conditions and midlife environment play a significant role in survival to advanced ages. However, little is known about the simultaneous effects of these three factors on longevity. This ongoing study attempts to fill this gap by comparing centenarians born in the United States in 1890–91 with peers born in the same years who died at age 65. The records for centenarians and controls were taken from computerized family histories, which were then linked to 1900 and 1930 U.S. censuses. As a result of this linkage procedure, 765 records of confirmed centenarians and 783 records of controls were obtained.

Analysis with multivariate logistic regression found that parental longevity and some midlife characteristics proved to be significant predictors of longevity while the role of childhood conditions was less important. More centenarians were born in the second half of the year compared to controls, suggesting early origins of longevity. We found the existence of both general and gender-specific predictors of human longevity. General predictors common for men and women are paternal and maternal longevity. Gender-specific predictors of male longevity are the farmer occupation at age 40, Northeastern region of birth in the United States and birth in the second half of year. A gender-specific predictor of female longevity is surprisingly the availability of radio in the household according to the 1930 U.S. census.

Given the importance of familial longevity as an independent predictor of survival to advanced ages, we conducted a comparative study of biological and nonbiological relatives of centenarians using a larger sample of 1,945 validated U.S. centenarians born in 1880–95. We found that male gender of centenarian has significant positive effect on survival of adult male relatives (brothers and fathers) but not female blood relatives. Life span of centenarian siblings-in-law is lower compared to life span of centenarian siblings and does not depend on centenarian gender. Wives of male centenarians (who share lifestyle and living conditions) have a significantly better survival compared to wives of centenarians’ brothers. This finding demonstrates an important role of shared familial environment and lifestyle in human longevity.

The results of this study suggest that familial background, early-life conditions and midlife characteristics play an important role in longevity. This study was supported by National Institutes of Health (NIH) grant R01 AG028620.

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