Friday, August 01, 2008

Life-Extension Drugs

Dear All,

I would greatly appreciate your advice, please, on any recent review of life-extension drugs, when applied to animal models (mice, rats, etc.).

Specifically, what are the typical effect sizes for these drugs in terms of percent increase in median lifespan (50% survival time)?

Are there some typical examples of drugs for the following specific life-extension patterns:

1. Improving the early survival only ("rectangularization" of the survival curve).
Also when/if this happens, is there a delay in onset of any other symptoms of aging?

2. Improving survival at all ages (parallel shift of the survival curve to older ages).

3. Improving the old-age survival only ("de-rectangularization" of the survival curve).

Please advise, by posting your comments here.

Thank you!

-- Leonid Gavrilov, Ph.D.
Website: http://longevity-science.org/
Blog: http://longevity-science.blogspot.com/
My books: http://longevity-science.org/Books.html

P.S. Here is what I have found so far:

Life Extending Interventions

Intervention Name (In Alphabetic order), Organism, Aging Phenotype

(R)-N-(2-heptyl)-N-methylpropargylamine, Drosophila melanogaster, No effect on life-span,
2-mercaptoethanol , Mus musculus, Life-span extension
2-mercaptoethylamine hydrochloride, Mus musculus, Life-span extension
60% Oxygen, Rattus norvegicus, Shortened life-span

A
Ablation of dilp2 producing neurosecretory cells, Drosophila melanogaster, Life-span extension Accelerated photoperiodic cycle, Microcebus murinus, Shortened life-span
Acetyl-L-Carnitine, Rattus norvegicus, N/A
alpha-phenyl-N-t-butyl-nitrone, Homo sapiens (cell culture), Life-span extension
alpha-phenyl-N-t-butyl-nitrone, Mus musculus, Life-span extension
alpha-phenyl-N-t-butyl-nitrone, Musca domestica, Shortened life-span
Antimycin A , Caenorhabditis elegans, Life-span extension
Antimycin A, Saccharomyces cerevisiae (chronological), Shortened life-span
antioxidant drug EUK-134, Musca domestica, Shortened life-span
antioxidant drug EUK-134, Caenorhabditis elegans, Life-span extension
antioxidant drug EUK-8, Musca domestica, Shortened life-span
antioxidant drug EUK-8, Caenorhabditis elegans, Shortened life-span
antioxidant drug EUK-8, Caenorhabditis elegans, Life-span extension
Antioxidant treatment, Rattus norvegicus, No effect on life-span
Axenic growth, Caenorhabditis elegans, Life-span extension

B
Butein , Saccharomyces cerevisiae (replicative), Life-span extension
Butylated hydroxy anisole, Zaprionus paravittiger, Life-span extension
Butylated hydroxytoluene, Drosophila bipectinata, Life-span extension

C
Caloric restriction, Macaca mulatta, N/A
Caloric restriction, Rattus norvegicus, Life-span extension
Caloric restriction, Saccharomyces cerevisiae (replicative), Life-span extension
Caloric restriction, Caenorhabditis elegans, Life-span extension
Caloric restriction, Drosophila melanogaster, Life-span extension
Caloric restriction, Frontinella pyramitela, Life-span extension
Caloric restriction, Canis lupus familiaris, Life-span extension
Caloric restriction, Ceratitis capitata, No effect on life-span
Caloric restriction, Asplanchna brightwelli, Life-span extension
Caloric restriction, Lebistes reticulatus, Life-span extension
Caloric restriction , Daphnia pulex, Life-span extension
Caloric restriction Brachionus calyciflorus Life-span extension
Caloric restriction Asplanchna girodi Life-span extension
Caloric restriction Brachionus patulus Life-span extension
Caloric restriction Brachionus plicatilis Shortened life-span
Caloric restriction Euclanis dilatata Life-span extension
Caloric restriction Encentrum linnhei Life-span extension
Caloric restriction Keratella testudo Shortened life-span
Caloric restriction Philodina acuticornis Life-span extension
Caloric restriction Synchaeta pectinata Shortened life-span
Caloric restriction Tokophrya infusionum Life-span extension
Caloric restriction Homo sapiens N/A
Caloric restriction Mus musculus Life-span extension
CDTA Drosophila melanogaster Life-span extension
Cold stress Haematobia irritans Life-span extension
Continuous dark Asplanchna brightwelli Life-span extension
Copper gluconate Mus musculus Shortened life-span
Cortisone Asplanchna brightwelli Life-span extension
Curare Asplanchna brightwelli Life-span extension

D
D-glucosamine Saccharomyces cerevisiae (replicative) No effect on life-span
D-Glucose Saccharomyces cerevisiae (replicative) Life-span extension
D-Glycerol Saccharomyces cerevisiae (replicative) Life-span extension
D-sorbitol Saccharomyces cerevisiae (replicative) Life-span extension
D-Xylitol Saccharomyces cerevisiae (replicative) Life-span extension
Decreased oxygen concentration Homo sapiens (cell culture) Life-span extension
Decreased temperature Asplanchna brightwelli Life-span extension
deprenyl Rattus norvegicus Life-span extension
deprenyl Mesocricetus auratus Life-span extension
deprenyl Canis lupus familiaris Life-span extension
deprenyl Mus musculus Life-span extension
deprenyl Drosophila melanogaster No effect on life-span
deprenyl Rattus norvegicus Shortened life-span
Dietary cadmium Drosophila melanogaster Shortened life-span
Dietary iron Drosophila melanogaster Correlation
Dietary restriction of coenzyme Q Caenorhabditis elegans Life-span extension
Dietary restriction of coenzyme Q Drosophila melanogaster Shortened life-span
Diiodomethane Drosophila melanogaster Life-span extension
Diphenylhydantoin Mus musculus Life-span extension
DNA and RNA Injection Rattus norvegicus Life-span extension

E
Ectopic extrachromosomal rDNA circle (ERC) induction. Saccharomyces cerevisiae (replicative) Shortened life-span
EDTA Mytilina brevispina var redunca Life-span extension
EGb 761 Caenorhabditis elegans Life-span extension
EGTA Mytilina brevispina var redunca Life-span extension
Epithalamin Drosophila melanogaster Life-span extension
Ethoxyquin Mus musculus Life-span extension
Exercise Mus musculus No effect on life-span
Exercise Rattus norvegicus Life-span extension

F
FCCP Saccharomyces cerevisiae (chronological) Life-span extension
Fisetin Saccharomyces cerevisiae (replicative) Life-span extension
Fish oil Mus musculus Life-span extension

G
Galactose feeding Drosophila melanogaster Shortened life-span
germ line ablation Caenorhabditis elegans Life-span extension
germ line ablation Pristionchus pacificus Life-span extension
Growth on carbenicillin treated bacteria Caenorhabditis elegans Life-span extension
Growth on kanamycin treated bacteria Caenorhabditis elegans Life-span extension
Growth on UV-killed bacteria Caenorhabditis elegans Life-span extension

H
Heat Shock Saccharomyces cerevisiae (replicative) Life-span extension
Heat Shock Caenorhabditis elegans Life-span extension
Heat Shock Drosophila melanogaster Life-span extension
Hibernation Mesocricetus brandti Life-span extension
High Osmolarity Saccharomyces cerevisiae (replicative) Life-span extension
Human Growth Hormone Therapy Rattus norvegicus No effect on life-span
Human Growth Hormone Therapy Homo sapiens N/A
Human Growth Hormone Therapy Mus musculus No effect on life-span
Hypergravity Drosophila melanogaster Life-span extension

K
Kinetin dietary supplementation Zaprionus paravittiger Life-span extension

L
L- carnosine Homo sapiens (cell culture) Life-span extension

M
Magnesium thiazolidine-4-carboxylic acid Aedes aegypti Life-span extension
Melatonin Mus musculus Life-span extension
Melatonin Drosophila melanogaster No effect on life-span
Melatonin Drosophila melanogaster Life-span extension
Methionine Mus musculus Shortened life-span
Methionine Zaprionus paravittiger Life-span extension
Methionine restriction Rattus norvegicus Life-span extension
Methionine restriction Mus musculus Life-span extension
Modified Mediterranean diet Homo sapiens Correlation

N
N,N'-diphenyl-1,4-diphenylenediamine Caenorhabditis elegans No effect on life-span
N-acetylcysteine Drosophila melanogaster Life-span extension
N-benzyl hydroxylamine Homo sapiens (cell culture) Life-span extension
N-methyl hydroxylamine Homo sapiens (cell culture) Life-span extension
N-t-butyl hydroxylamine Homo sapiens (cell culture) Life-span extension
Nicotinamide Homo sapiens (cell culture) No effect on life-span
Nicotinamide Saccharomyces cerevisiae (replicative) Shortened life-span
Nicotinic Acid Saccharomyces cerevisiae (replicative) No effect on life-span Nordihydroguaiaretic acid Aedes aegypti Life-span extension

O
Ovary transplantation Mus musculus Life-span extension
Oxygen pretreatment Caenorhabditis elegans Life-span extension

P
Paraquat Saccharomyces cerevisiae (chronological) Shortened life-span
PBA Drosophila melanogaster Life-span extension
Phenformin Mus musculus Life-span extension
Prevention of flight Musca domestica Life-span extension
Prevention of mating (by removal of females) Drosophila melanogaster Life-span extension Propyl gallate Zaprionus paravittiger Life-span extension

R
R-Alpha-Lipoic Acid Rattus norvegicus N/A
Repeated Mild Heat Shock Homo sapiens (cell culture) No effect on life-span
Resveratrol Saccharomyces cerevisiae (replicative) Life-span extension
Resveratrol Saccharomyces cerevisiae (chronological) No effect on life-span
Resveratrol Caenorhabditis elegans Life-span extension
Resveratrol Drosophila melanogaster Life-span extension
Resveratrol Saccharomyces cerevisiae (replicative) No effect on life-span
Retinoic acid Homo sapiens (cell culture) Life-span extension
Royal Jelly Mus musculus Life-span extension

S
Sodium borate Drosophila melanogaster Life-span extension
Sodium citrate Mytilina brevispina var redunca Life-span extension
Sodium cyanide Saccharomyces cerevisiae (chronological) Life-span extension
Sodium hypophosphite Zaprionus paravittiger Life-span extension
Sodium selenite Zaprionus paravittiger Life-span extension
sodium tartrate Mytilina brevispina var redunca Life-span extension

T
Tamarixetin Caenorhabditis elegans Life-span extension
Tea extract Drosophila melanogaster Life-span extension
Telomere length Saccharomyces cerevisiae (replicative) N/A
Thyroxine Rattus norvegicus Life-span extension
Tryptophan Restriction Mus musculus Life-span extension
Tryptophan Restriction Rattus norvegicus Life-span extension

U
UV radiation Asplanchna brightwelli Shortened life-span

V
Vitamin C Caenorhabditis elegans No effect on life-span
Vitamin C Homo sapiens (cell culture) Life-span extension
Vitamin E Asplanchna brightwelli Life-span extension
Vitamin E Zaprionus paravittiger Life-span extension
Vitamin E Philodina acuticornis Life-span extension
Vitamin E Mus musculus No effect on life-span
Vitamin E Caenorhabditis elegans No effect on life-span
Vitamin E Caenorhabditis elegans Life-span extension

Home:
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Longevity Science: Life-Extension Drugs
Shorter weblink:
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11 Comments:

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5:53 AM  
Anonymous Robert F. Wolf said...

I hope you can make use of this article I just read in an old issue of the journal Science. The date is January 14, 2005; I'm a bit behind in my reading but Volume 307, page 258 has a fine article entitled "Anticonvulsant Medications Extend Worm Life-Span". The life span of C. elegans worms were extended 50% by trimethadione and ethosuximide, drugs already in use in humans. This great news is from Washington Univ. in my hometown of St. Louis. I am now looking for more research in this area. Thank you, Robert Wolf

6:30 PM  
Anonymous Len Footland said...

What about pyridoxamine and/or benfotiamine preventing AGE's?

1:06 AM  
Blogger Linwood Duncan said...

This comment has been removed by the author.

5:11 AM  
Blogger Linwood Duncan said...

This comment has been removed by the author.

5:14 AM  
Anonymous Linwood Duncan said...

After studying the effects of Resveratrol in scientific studies I feel it has cured my Alzheimer’s disease. I love Resveratrol!

5:20 AM  
Blogger Piper said...

I've been taking resveratrol as a food supplement and I must say that I'm thankful to a friend who told me where to buy resveratrol. Some of the things I like most about it are its anti-cancer and anti-aging properties. I think this is the only "life-extending" product I'll ever need.

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