'Science Against Aging' Research Plan -- Invitation to Discussion

See also:
-- 'Books Forum' blog
-- 'Health Studies' blog


Dear All:

You are cordially invited to participate in discussion of a new 'Science Against Aging' Research Plan:

http://longevity-science.org/SCIENCE_AGAINST_AGING_RESEARCH_PLAN.pdf
Shorter weblink:
http://tinyurl.com/df2kvg

The authors of this program wrote:

Please, answer 12 basic questions on the biology of ageing:

1. Why are organisms exposed to progressive and irreversible reduction of physiological functions in the final period of their lives?

2 . Why do life expectancy and speed of aging differ within one species and across species?

3. Why does experimental treatment such as caloric restriction delay a great number of age-related physiological and pathological changes and increase the average and maximum life duration in animals?

4. Do these factors affect aging and age-associated diseases independently from one another?

5. Do age-related changes in the organism increase the exposure to diseases or do diseases develop independently and only later exacerbate the manifestations of aging?

6. What are, in your view, possible points of a scientific breakthrough in research aimed at increase of longevity?

7. At what evolutionary phase did aging arise or, alternatively, has it accompanied life since its inception?

8. Are the aging processes of an organism caused by aging at the cell level?

9. To what extent are aging processes conditioned genetically?

10. Why do species with 'negligible' aging exist?

11. Are reproduction and life expectancy interrelated or independent from each other?

12. What other questions may be crucial for understanding the mechanisms of aging?

The authors of this program also invited to comment on the sections of their Research Plan:

Section 1
Fundamental Mechanisms of Aging. Main Research Areas

Section 2
Genetics of Lifespan and Aging. Main Research Directions

Section 3
Metabolic Aspects of Aging and Longevity. Main Research Directions

Section 4
Immunity and Aging. Main Research Directions

Section 5
Stem Cells and Aging. Main Research Directions

Section 6
Application of Stem Cells in Geriatrics & Gerontology. Main Research Directions

Section 7
Medicated Geroprotection. Main Research Directions

Section 8
Geroprotectors Efficiency Research. Main Research Directions

Section 9
Identification of the Molecular Markers in Aging. Selected Clauses

Section 10
Mathematical Modelling of the Life Span, Longevity and Aging. Main Research Directions

Section 11
Microecology and Aging. Main Research Directions

Section 12
Reproduction and Aging. Selected Research Directions

Section 13
Environmental Influence on Aging. Selected Research Directions

The Word "doc" version of the entire Program is available at:

http://longevity-science.org/SCIENCE_AGAINST_AGING_RESEARCH_PLAN.doc
Shorter weblink:
http://tinyurl.com/c7e358

Please feel free to post your comments and suggestions below by clicking here.


Key words:
Science Against Aging, Fundamental Mechanisms of Aging, Genetics of Lifespan and Aging, Metabolic Aspects of Aging and Longevity, Immunity and Aging, Stem Cells and Aging, Application of Stem Cells in Geriatrics & Gerontology, Medicated Geroprotection, Geroprotectors Efficiency, Molecular Markers in Aging, Mathematical Modelling of the Life Span, Longevity and Aging; Microecology and Aging; Reproduction and Aging; Environmental Influence on Aging


Home:
Longevity Science Blog
and
'Science Against Aging' Research Plan -- Invitation to Discussion
Shorter weblink:
http://tinyurl.com/cxhxs8


.

Upcoming Meeting on Life-Extension (SENS) in England, September 2009

See also:
-- 'Books Forum' blog
-- 'Health Studies' blog


Dear All:

Here is an interesting announcement I have got recently about the upcoming meeting on life-extension (SENS) in Cambridge, England, September 3-7, 2009:

My apologies if you receive this email more than once. Please forward it to any colleagues who you feel may be interested.

I am writing to notify you that registration and abstract submission are now open for the fourth Strategies for Engineered Negligible Senescence (SENS) conference, to be held at Queens' College, Cambridge, England on September 3rd-7th 2009. The early registration and abstract submission deadlines are both June 15th. All details, including forms for abstract submission and online registration, are at the conference website:

http://www.mfoundation.org/sens4

The preliminary program already has 35 confirmed speakers, all of them world leaders in their field. As for previous SENS conferences, the emphasis of this meeting is on "applied gerontology" - the design and implementation of biomedical interventions that may, jointly, constitute a comprehensive panel of rejuvenation therapies, sufficient to restore middle-aged or older laboratory animals (and, in due course, humans) to a youthful degree of physiological robustness. The list of sessions and confirmed speakers is as follows:

Making metabolism less harmful:
Vladimir Skulachev, Holly Brown-Borg, Stephen Spindler, Stephen Vatner

Spontaneous regeneration:
Brandon Reines, Jonathan Tilly, Alexandra Stolzing

Eliminating recalcitrant intracellular molecules:
William Sly, Ana Maria Cuervo, John Schloendorn, Claude Wischik, Martin Hetzer

Rejuvenating extracellular material:
Nik Nikitin, Mark Pepys, Sudhir Paul, Mark Noble, Kendall Houk

Novel anti-cancer approaches:
Paul Hallenbeck, Adela Ben-Yakar, Vera Gorbunova, Maria Blasco, David Keefe

Rejuvenating the immune system:
Janko Nikolich-Zugich, Anne de Groot

ES-like cells and cell therapy:
Justin Ichida, Ilham Abuljadayel, Thomas Zwaka, Daniel Kraft, John Sladek, Dan Gazit

Tissue engineering:
Augustinus Bader, Gabor Forgacs

The defeat of aging and its consequences:
Philip Moriarty, Tanya Jones, Leonid Gavrilov

In addition, there will be at least a dozen short talks selected from submitted abstracts, as well as poster sessions each evening. Authors of short talks and posters will, like the invited speakers, be invited to submit a paper summarising their presentation for the proceedings volume, which will be published in the high-impact journal Rejuvenation Research early in 2010.

Please note that registration fees are fully inclusive of accommodation and all meals. Those not requiring accommodation, and journalists wishing to obtain free press passes (not including accommodation) are asked to contact me by email (aubrey@sens.org).

I hope to welcome you to Cambridge in September!

Cheers, Aubrey

Aubrey de Grey
Organiser, SENS4
Chairman and Chief Science Officer, Methuselah Foundation
Editor-in-Chief, Rejuvenation Research

-------------END--------------------


Key words:
SENS, Life-Extension, Aubrey de Grey, rejuvenation research, Leonid Gavrilov, Strategies for Engineered Negligible Senescence, anti-ageing, anti-aging, ageing, aging, longevity


Home:
Longevity Science Blog
and
Upcoming Meeting on Life-Extension (SENS) in England, September 2009
Shorter weblink:
http://tinyurl.com/bhgevj




.

Life-Extension Drugs

Dear All,

I would greatly appreciate your advice, please, on any recent review of life-extension drugs, when applied to animal models (mice, rats, etc.).

Specifically, what are the typical effect sizes for these drugs in terms of percent increase in median lifespan (50% survival time)?

Are there some typical examples of drugs for the following specific life-extension patterns:

1. Improving the early survival only ("rectangularization" of the survival curve).
Also when/if this happens, is there a delay in onset of any other symptoms of aging?

2. Improving survival at all ages (parallel shift of the survival curve to older ages).

3. Improving the old-age survival only ("de-rectangularization" of the survival curve).

Please advise, by posting your comments here.

Thank you!

-- Leonid Gavrilov, Ph.D.
Website: http://longevity-science.org/
Blog: http://longevity-science.blogspot.com/
My books: http://longevity-science.org/Books.html

P.S. Here is what I have found so far:

Life Extending Interventions

Intervention Name (In Alphabetic order), Organism, Aging Phenotype

(R)-N-(2-heptyl)-N-methylpropargylamine, Drosophila melanogaster, No effect on life-span,
2-mercaptoethanol , Mus musculus, Life-span extension
2-mercaptoethylamine hydrochloride, Mus musculus, Life-span extension
60% Oxygen, Rattus norvegicus, Shortened life-span

A
Ablation of dilp2 producing neurosecretory cells, Drosophila melanogaster, Life-span extension Accelerated photoperiodic cycle, Microcebus murinus, Shortened life-span
Acetyl-L-Carnitine, Rattus norvegicus, N/A
alpha-phenyl-N-t-butyl-nitrone, Homo sapiens (cell culture), Life-span extension
alpha-phenyl-N-t-butyl-nitrone, Mus musculus, Life-span extension
alpha-phenyl-N-t-butyl-nitrone, Musca domestica, Shortened life-span
Antimycin A , Caenorhabditis elegans, Life-span extension
Antimycin A, Saccharomyces cerevisiae (chronological), Shortened life-span
antioxidant drug EUK-134, Musca domestica, Shortened life-span
antioxidant drug EUK-134, Caenorhabditis elegans, Life-span extension
antioxidant drug EUK-8, Musca domestica, Shortened life-span
antioxidant drug EUK-8, Caenorhabditis elegans, Shortened life-span
antioxidant drug EUK-8, Caenorhabditis elegans, Life-span extension
Antioxidant treatment, Rattus norvegicus, No effect on life-span
Axenic growth, Caenorhabditis elegans, Life-span extension

B
Butein , Saccharomyces cerevisiae (replicative), Life-span extension
Butylated hydroxy anisole, Zaprionus paravittiger, Life-span extension
Butylated hydroxytoluene, Drosophila bipectinata, Life-span extension

C
Caloric restriction, Macaca mulatta, N/A
Caloric restriction, Rattus norvegicus, Life-span extension
Caloric restriction, Saccharomyces cerevisiae (replicative), Life-span extension
Caloric restriction, Caenorhabditis elegans, Life-span extension
Caloric restriction, Drosophila melanogaster, Life-span extension
Caloric restriction, Frontinella pyramitela, Life-span extension
Caloric restriction, Canis lupus familiaris, Life-span extension
Caloric restriction, Ceratitis capitata, No effect on life-span
Caloric restriction, Asplanchna brightwelli, Life-span extension
Caloric restriction, Lebistes reticulatus, Life-span extension
Caloric restriction , Daphnia pulex, Life-span extension
Caloric restriction Brachionus calyciflorus Life-span extension
Caloric restriction Asplanchna girodi Life-span extension
Caloric restriction Brachionus patulus Life-span extension
Caloric restriction Brachionus plicatilis Shortened life-span
Caloric restriction Euclanis dilatata Life-span extension
Caloric restriction Encentrum linnhei Life-span extension
Caloric restriction Keratella testudo Shortened life-span
Caloric restriction Philodina acuticornis Life-span extension
Caloric restriction Synchaeta pectinata Shortened life-span
Caloric restriction Tokophrya infusionum Life-span extension
Caloric restriction Homo sapiens N/A
Caloric restriction Mus musculus Life-span extension
CDTA Drosophila melanogaster Life-span extension
Cold stress Haematobia irritans Life-span extension
Continuous dark Asplanchna brightwelli Life-span extension
Copper gluconate Mus musculus Shortened life-span
Cortisone Asplanchna brightwelli Life-span extension
Curare Asplanchna brightwelli Life-span extension

D
D-glucosamine Saccharomyces cerevisiae (replicative) No effect on life-span
D-Glucose Saccharomyces cerevisiae (replicative) Life-span extension
D-Glycerol Saccharomyces cerevisiae (replicative) Life-span extension
D-sorbitol Saccharomyces cerevisiae (replicative) Life-span extension
D-Xylitol Saccharomyces cerevisiae (replicative) Life-span extension
Decreased oxygen concentration Homo sapiens (cell culture) Life-span extension
Decreased temperature Asplanchna brightwelli Life-span extension
deprenyl Rattus norvegicus Life-span extension
deprenyl Mesocricetus auratus Life-span extension
deprenyl Canis lupus familiaris Life-span extension
deprenyl Mus musculus Life-span extension
deprenyl Drosophila melanogaster No effect on life-span
deprenyl Rattus norvegicus Shortened life-span
Dietary cadmium Drosophila melanogaster Shortened life-span
Dietary iron Drosophila melanogaster Correlation
Dietary restriction of coenzyme Q Caenorhabditis elegans Life-span extension
Dietary restriction of coenzyme Q Drosophila melanogaster Shortened life-span
Diiodomethane Drosophila melanogaster Life-span extension
Diphenylhydantoin Mus musculus Life-span extension
DNA and RNA Injection Rattus norvegicus Life-span extension

E
Ectopic extrachromosomal rDNA circle (ERC) induction. Saccharomyces cerevisiae (replicative) Shortened life-span
EDTA Mytilina brevispina var redunca Life-span extension
EGb 761 Caenorhabditis elegans Life-span extension
EGTA Mytilina brevispina var redunca Life-span extension
Epithalamin Drosophila melanogaster Life-span extension
Ethoxyquin Mus musculus Life-span extension
Exercise Mus musculus No effect on life-span
Exercise Rattus norvegicus Life-span extension

F
FCCP Saccharomyces cerevisiae (chronological) Life-span extension
Fisetin Saccharomyces cerevisiae (replicative) Life-span extension
Fish oil Mus musculus Life-span extension

G
Galactose feeding Drosophila melanogaster Shortened life-span
germ line ablation Caenorhabditis elegans Life-span extension
germ line ablation Pristionchus pacificus Life-span extension
Growth on carbenicillin treated bacteria Caenorhabditis elegans Life-span extension
Growth on kanamycin treated bacteria Caenorhabditis elegans Life-span extension
Growth on UV-killed bacteria Caenorhabditis elegans Life-span extension

H
Heat Shock Saccharomyces cerevisiae (replicative) Life-span extension
Heat Shock Caenorhabditis elegans Life-span extension
Heat Shock Drosophila melanogaster Life-span extension
Hibernation Mesocricetus brandti Life-span extension
High Osmolarity Saccharomyces cerevisiae (replicative) Life-span extension
Human Growth Hormone Therapy Rattus norvegicus No effect on life-span
Human Growth Hormone Therapy Homo sapiens N/A
Human Growth Hormone Therapy Mus musculus No effect on life-span
Hypergravity Drosophila melanogaster Life-span extension

K
Kinetin dietary supplementation Zaprionus paravittiger Life-span extension

L
L- carnosine Homo sapiens (cell culture) Life-span extension

M
Magnesium thiazolidine-4-carboxylic acid Aedes aegypti Life-span extension
Melatonin Mus musculus Life-span extension
Melatonin Drosophila melanogaster No effect on life-span
Melatonin Drosophila melanogaster Life-span extension
Methionine Mus musculus Shortened life-span
Methionine Zaprionus paravittiger Life-span extension
Methionine restriction Rattus norvegicus Life-span extension
Methionine restriction Mus musculus Life-span extension
Modified Mediterranean diet Homo sapiens Correlation

N
N,N'-diphenyl-1,4-diphenylenediamine Caenorhabditis elegans No effect on life-span
N-acetylcysteine Drosophila melanogaster Life-span extension
N-benzyl hydroxylamine Homo sapiens (cell culture) Life-span extension
N-methyl hydroxylamine Homo sapiens (cell culture) Life-span extension
N-t-butyl hydroxylamine Homo sapiens (cell culture) Life-span extension
Nicotinamide Homo sapiens (cell culture) No effect on life-span
Nicotinamide Saccharomyces cerevisiae (replicative) Shortened life-span
Nicotinic Acid Saccharomyces cerevisiae (replicative) No effect on life-span Nordihydroguaiaretic acid Aedes aegypti Life-span extension

O
Ovary transplantation Mus musculus Life-span extension
Oxygen pretreatment Caenorhabditis elegans Life-span extension

P
Paraquat Saccharomyces cerevisiae (chronological) Shortened life-span
PBA Drosophila melanogaster Life-span extension
Phenformin Mus musculus Life-span extension
Prevention of flight Musca domestica Life-span extension
Prevention of mating (by removal of females) Drosophila melanogaster Life-span extension Propyl gallate Zaprionus paravittiger Life-span extension

R
R-Alpha-Lipoic Acid Rattus norvegicus N/A
Repeated Mild Heat Shock Homo sapiens (cell culture) No effect on life-span
Resveratrol Saccharomyces cerevisiae (replicative) Life-span extension
Resveratrol Saccharomyces cerevisiae (chronological) No effect on life-span
Resveratrol Caenorhabditis elegans Life-span extension
Resveratrol Drosophila melanogaster Life-span extension
Resveratrol Saccharomyces cerevisiae (replicative) No effect on life-span
Retinoic acid Homo sapiens (cell culture) Life-span extension
Royal Jelly Mus musculus Life-span extension

S
Sodium borate Drosophila melanogaster Life-span extension
Sodium citrate Mytilina brevispina var redunca Life-span extension
Sodium cyanide Saccharomyces cerevisiae (chronological) Life-span extension
Sodium hypophosphite Zaprionus paravittiger Life-span extension
Sodium selenite Zaprionus paravittiger Life-span extension
sodium tartrate Mytilina brevispina var redunca Life-span extension

T
Tamarixetin Caenorhabditis elegans Life-span extension
Tea extract Drosophila melanogaster Life-span extension
Telomere length Saccharomyces cerevisiae (replicative) N/A
Thyroxine Rattus norvegicus Life-span extension
Tryptophan Restriction Mus musculus Life-span extension
Tryptophan Restriction Rattus norvegicus Life-span extension

U
UV radiation Asplanchna brightwelli Shortened life-span

V
Vitamin C Caenorhabditis elegans No effect on life-span
Vitamin C Homo sapiens (cell culture) Life-span extension
Vitamin E Asplanchna brightwelli Life-span extension
Vitamin E Zaprionus paravittiger Life-span extension
Vitamin E Philodina acuticornis Life-span extension
Vitamin E Mus musculus No effect on life-span
Vitamin E Caenorhabditis elegans No effect on life-span
Vitamin E Caenorhabditis elegans Life-span extension

Home:
Longevity Science Blog
and
Longevity Science: Life-Extension Drugs
Shorter weblink:
http://tinyurl.com/62b78o


.

New Initiative to Combat Human Aging

See also:
-- 'Books Forum' blog
-- 'Health Studies' blog


Greetings,

I am pleased to inform you that the new issue of The New England Journal of Medicine reviews the idea of a dramatic acceleration of anti-aging research ("Apollo-type effort to control aging") through greatly increased research funding:

The New England Journal of Medicine, 2008, 358(20): 2187-2188
http://content.nejm.org/cgi/content/short/358/20/2187

Here are some excerpts from this published book review:

The Longevity Revolution:
The Benefits and Challenges of Living a Long Life
by Dr. Robert N. Butler

"This book about the ongoing revolution in human longevity and its implications for society was written by Robert Butler, a professor of geriatrics who is still working at the age of 80. The book is unique in that Butler not only describes the medical and social problems that can be anticipated in the United States when baby boomers reach retirement age but also suggests bold and radical solutions for these upcoming problems.

Butler was the founding director of the National Institute on Aging of the National Institutes of Health from 1976 to 1982, and given his impressive background, his extraordinary plan of action should be considered very seriously.

The main premise of the book is that the anticipated catastrophic increases in rates of disability and the cost of health care among older people could be avoided if the United States committed itself to a large-scale scientific project akin to NASA's Apollo program of flights to the moon.

Butler states that his proposed program "could be dubbed the Apollo Program for Aging and Longevity Science" and goes on to explain that "the present level of development of aging and longevity research justifies an Apollo-type effort to control aging. . . . Now we have both past work as a foundation and new scientific tools offering hope that we may soon have a more prolonged, vigorous and productive life and added longevity. During the twenty-first century, the century of the life sciences, longevity science should truly come of age."

Butler believes that "it may soon be possible to delay both aging and age-related disease in humans" but that "an orbital jump in financing of science is required to advance longevity and health as well as national wealth."

Today, less than 1% of the entire federal budget is spent on medical research. Butler proposes that to improve health and control costs, 3% of the federal government's annual spending on health care should be made available to the National Institutes of Health for medical research. He also proposes that of Medicare expenditures, 1% should be earmarked for the National Institute on Aging. This investment should increase in line with the Medicare budget, but according to Butler, scientific research could lower Medicare expenditures.

Butler concludes that "while the numbers I am suggesting may seem extraordinary, I believe the level of scientific progress in the field since the 1950s justifies such a program. . . ."

As a former director of the National Institute on Aging, Butler understands well where the main wasting of scientific potential currently takes place. As many as 80 to 85% of all research proposals that are peer reviewed and approved (scored) by the National Institutes of Health cannot be funded. This is a tremendous loss of intellectual potential and research opportunities.

With his suggested increase in funding, Butler believes that "at least 30 percent of approved grants (if not more) should be funded." In short, to meet the challenges of the aging population, we need a scientific revolution in the science and medicine of longevity. Butler writes, "Science will find new ways to extend life and its quality. Evidence suggests that morbidity can be further compressed, and society can adapt to the growing numbers of older persons." ...

This book has the potential to change the future of this country for the better if its ideas reach members of Congress and other representatives of the U.S. government."

...

----------- THE END --------------------------------

Source:
The New England Journal of Medicine, 2008, 358(20): 2187-2188
http://content.nejm.org/cgi/content/short/358/20/2187

Disclaimer
The authors of this new publication are:

-- Leonid Gavrilov, Ph.D.
-- Natalia Gavrilova, Ph.D.
Center on Aging
University of Chicago
Chicago, IL 60637
gavrilov@longevity-science.org

Do you have any comments on this story?
Post them below by clicking here !


Home:
Longevity Science Blog
and
New Initiative to Combat Human Aging
Shorter weblink:
http://tinyurl.com/5x5ror


.

Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime

See also:
-- 'Books Forum' blog
-- 'Health Studies' blog


Greetings,

Here is a book for discussion:

Ending Aging:
The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime
by Aubrey de Grey and Michael Rae (Hardcover - Sep 4, 2007)

Book Description provided by the Publisher (St. Martin's Press):

MUST WE AGE? A long life in a healthy, vigorous, youthful body has always been one of humanity's greatest dreams. Recent progress in genetic manipulations and calorie-restricted diets in laboratory animals hold forth the promise that someday science will enable us to exert total control over our own biological aging. Nearly all scientists who study the biology of aging agree that we will someday be able to substantially slow down the aging process, extending our productive, youthful lives. Dr. Aubrey de Grey is perhaps the most bullish of all such researchers. As has been reported in media outlets ranging from 60 Minutes to The New York Times, Dr. de Grey believes that the key biomedical technology required to eliminate aging-derived debilitation and death entirely-technology that would not only slow but periodically reverse age-related physiological decay, leaving us biologically young into an indefinite future-is now within reach. In Ending Aging, Dr. de Grey and his research assistant Michael Rae describe the details of this biotechnology.

They explain that the aging of the human body, just like the aging of man-made machines, results from an accumulation of various types of damage. As with man-made machines, this damage can periodically be repaired, leading to indefinite extension of the machine's fully functional lifetime, just as is routinely done with classic cars. We already know what types of damage accumulate in the human body, and we are moving rapidly toward the comprehensive development of technologies to remove that damage. By demystifying aging and its postponement for the nonspecialist reader, de Grey and Rae systematically dismantle the fatalist presumption that aging will forever defeat the efforts of medical science.


From the Back Cover:

People alive today could live to be a thousand years old

“His clarion call to action is the message neither of a madman nor a bad man, but of a brilliant, beneficent man of goodwill, who wants only for civilization to fulfill the highest hopes he has for its future.”
­Dr. Sherwin Nuland, clinical professor of surgery at Yale University School of Medicine and author of How We Die and The Art of Aging

“Seems to me this man could be put in jail with reasonable cause.”
­Dr. Martin Raff, emeritus professor of biology at University College London and coauthor of Molecular Biology of the Cell

A leading researcher sketches the real “fountain of youth”

- The most realistic way to combat aging is to rejuvenate the body at the molecular and cellular level, removing accumulated damage and restoring us to a biologically younger state.

- Comprehensive rejuvenation therapies can feasibly postpone age-related frailty and disease indefinitely, greatly extending our lives while eliminating, rather than lengthening, the period of late-life frailty and debilitation.

- A comprehensive panel of rejuvenation therapies could probably be validated in laboratory mice within a decade. We would then have a good chance of developing it for human use only a decade or two thereafter.

- Removing the causes of aging-related deaths will also eliminate all the suffering that aging inflicts on most people in the last years of their lives.

- Aging kills 100,000 people a day: old people, yes, but old people are people too. Social concerns about the effects of defeating aging are legitimate but don’t outweigh the merits of saving so many lives and alleviating so much suffering.

Key words:
New books, aging, ageing, longevity, gerontology, gerontological, geriatrics, geriatric, senescence, anti-aging, anti-ageing, rejuvenation, life-extension, immortality, Ending Aging, Rejuvenation Breakthroughs, Reverse Human Aging, Aubrey de Grey, Michael Rae, St. Martin's Press

Do you have any comments on this new book?
Post them below by clicking here!

Home:
Longevity Science Blog
and
Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime
Shorter weblink:
http://tinyurl.com/2psceq


.

The Scientific Conquest of Death -- Book Discussion

See also:
-- 'Books Forum' blog
-- 'Health Studies' blog


Greetings,

Here is a book for discussion:

The Scientific Conquest of Death
by Immortality Institute

Book Description provided by the Publisher (Libros en Red):

Nineteen scientists, doctors and philosophers share their perspective on what is arguably the most significant scientific development that humanity has ever faced - the eradication of aging and mortality. This anthology is both a gentle introduction to the multitude of cutting-edge scientific developments, and a thoughtful, multidisciplinary discussion of the ethics, politics and philosophy behind the scientific conquest of aging.

Key words:
New books, aging, ageing, longevity, gerontology, gerontological, geriatrics, geriatric, senescence, anti-aging, anti-ageing, rejuvenation, life-extension, immortality, The Scientific Conquest of Death, Immortality Institute, Libros en Red, involuntary death, biological immortality, regenerative medicine, quest for immortality, human aging, life extension, Max More, Aubrey de Grey, The Basic Epicurean Argument, Alcor Life Extension Foundation, Pope John Paul, Russell Blackford, World Population Prospects, World War

Do you have any comments on this new book?
Post them below by clicking here!

Home:
Longevity Science Blog
and
The Scientific Conquest of Death -- Book Discussion
Shorter weblink:
http://tinyurl.com/ypzn62

.

New Recommendations on Anti-Aging Supplements

Greetings,

Recently I have come across this new book written by a medical doctor for lay public with practical recommendations what supplements to take in order to fight the aging of our brains:

The Brain Trust Program: A Scientifically Based Three-Part Plan to Improve Memory, Elevate Mood, Enhance Attention, Alleviate Migraine and Menopausal Symptoms, and Boost Mental Energy
by Larry McCleary, M.D.


Here is the new suggested anti-aging protocol for taking the following supplements:


Magnesium, 600 mg at bedtime

Taurine, 1 gram each morning and 1 gram each evening

Acetyl L-carnitine, 100-500 mg a day

Alpha-lipoic acid, 50-300 mg a day

Coenzyme Q10, 25-100 mg a day

Vitamin D, 400 IU in oil as a soft gel a day

Huperzine A, 75-100 mcg twice a day

Vinpocetine, 5-10 mg twice a day


Marine lipids:

-- eicosapentaenoic acid (EPA), 1-2 grams per day

-- docosahexaenoic acid (DHA), 1-2 grams per day

-- krill oil, 2-4 capsules per day


B vitamins (daily doses):

-- thiamin (B1), 20 mg

-- riboflavin (B2), 20 mg

-- niacin, 20 mg

-- pantothenic acid, 20 mg

-- biotin, 300 mg

-- pyridoxine (B6), 20 mg

-- cobalamin (B12), 100 mcg

-- folic acid, 800 mcg

-- choline, 20 mg

The book also suggests the so-called "Ketogenic Cocktail" to treat hot flashes in menopausal women:

-- Medium-chain triglycerides (MCT) oil, 1-2 tablespoons (about 15 grams/tablespoon)
-- Flaxseed oil, 1 teaspoon to 1 tablespoon
-- Eicosapentaenoic acid (EPA), 50 mg

It may be interesting to hear from the experts here, whether these supplements would really work, are their doses appropriate, and what side effects may be possible.

To share your knowledge, or perhaps even your personal experience in trying these supplements already, please post you comments below, by clicking here

Thank you!


By the way, this new book is now available at Amazon:





Home:
Longevity Science
and
New Recommendations on Anti-Aging Supplements
Shorter weblink:
http://tinyurl.com/yr9mw8

.

New Books on Aging, Longevity, Gerontology, Geriatrics, Life-Extension & Anti-Aging Interventions

New Books on Aging and Longevity Studies upcoming in January 2008.
You are most welcome to add new books here yourself if you do know some new interesting books!

See also the list of over 300 new books on Aging & Longevity published in 2007.


Greetings,

Here is the list of new books on aging and longevity, which will be published this month.

The books are listed in reversed chronological order (the most recent books are listed first). To get more information about these books, just click on the titles below:

1. Living Long and Loving It: Achieving a Healthy and Active Lifestyle
by Irvin M. Korr and Rene J. McGovern (Paperback - Jan 31, 2008)

2. Survival: The Survival of the Human Race (Darwin College Lectures)
by Emily Shuckburgh (Paperback - Jan 31, 2008)

3. microRNAs: From Basic Science to Disease Biology
by Sidney Altman, Victor R. Ambros, and Krishnarao Appasani (Hardcover - Jan 31, 2008)

4. Essentials of Geriatric Physical Therapy
by Jennifer M., Ph.D. Bottomley (Hardcover - Jan 31, 2008)

5. Blood Disorders in the Elderly
by Lodovico Balducci, William Ershler, and Giovanni de Gaetano (Hardcover - Jan 31, 2008)

6. Beat Memory Loss: The Complete Guide to Making the Most of Your Memory (Use Your Brain to Beat... S.)
by Rita Carter (Paperback - Jan 30, 2008)

7. Eternal Puppy: Keeping Your Dog Young Forever
by Janice Willard and Marty Becker (Paperback - Jan 30, 2008)

8. The Myth of Generational Conflict: The Family and State in Ageing Societies
by Sara Arber (Paperback - Jan 30, 2008)

9. Continence Care (Essential Clinical Skills for Nurses)
by Florence Mitchell (Paperback - Jan 30, 2008)

10. Smile for Life: Rejuvenation Dentistry and the Art of Wellness
by Gerald P. Curatola (Paperback - Jan 30, 2008)

11. Fatty Acid and Lipotoxicity in Obesity and Diabetes (Novartis Foundation Symposia)
by Novartis Foundation (Hardcover - Jan 28, 2008)

12. You and Your Aging Parent: A Family Guide to Emotional, Social, Health, and Financial Problems
by Barbara Silverstone and Helen Kandel Hyman (Paperback - Jan 28, 2008)

13. Tales of Graceful Aging from the Planet Denial (Thorndike Press Large Print Nonfiction Series)
by Nicole Hollander (Hardcover - Jan 22, 2008) - Large Print

14. Ultra-Longevity: The Seven-step Program for a Younger, Healthier You (Thorndike Large Print Health, Home and Learning)
by Mark Liponis (Hardcover - Jan 22, 2008) - Large Print

15. You, Staying Young: The Owner's Manual for Extending Your Warranty (Thorndike Large Print Health, Home and Learning)
by Mehmet, M.D. Oz and Michael F., M.D. Roizen (Hardcover - Jan 22, 2008) - Large Print

16. Social Policy in Ageing Societies: Britain and Germany Compared
by Gerhard Naegele and Alan Walker (Hardcover - Jan 22, 2008)

17. Reverse Heart Disease Now: Stop Deadly Cardiovascular Plaque Before It's Too Late
by Sinatra, James C., M.D. Roberts, and Martin Zucker (Paperback - Jan 18, 2008)

18. Adult Development and Aging
by Paul A Roodin and William J. Hoyer (Hardcover - Jan 15, 2008)

19. From Belly Fat to Belly Flat: How Your Hormones Are Adding Inches to Your Waist and Subtracting Years from Your Life -- the Medically Proven Way to Reset Your Metabolism and Reshape Your Body
by M.D., C.W. Randolph and Genie James (Paperback - Jan 15, 2008)

20. The Healthy Seniors Cookbook: Ideal Meals and Menus for People Over Sixty (Or Any Age)
by Marilyn McFarlane and Carol Baird (Paperback - Jan 15, 2008)

21. Senior Days: Insightful Tales and No-Nonsense Help from the Frontlines of Eldercare
by Colleen Nicol (Paperback - Jan 15, 2008)

22. Healthy Aging and Longevity: Third International Conference (Annals of the New York Academy of Sciences)
by Noah J. Weller and Suresh I. S. Rattan (Paperback - Jan 14, 2008)

23. The Natural Hormone Makeover: 10 Steps to Rejuvenate Your Health and Rediscover Your Inner Glow
by Phuli Cohan (Hardcover - Jan 14, 2008)

24. The Vitamin D Cure
by James Dowd and Diane Stafford (Hardcover - Jan 14, 2008)

25. Healthy Aging For Dummies (For Dummies (Health & Fitness))
by Brent Agin and Sharon, RN Perkins (Paperback - Jan 10, 2008)

26. The Myth of Alzheimer's: The Story of a Disease, a Doctor, and a New Direction for Aging in the 21st Century
by Whitehouse M.d., Peter J. ph.d, Danny George, and Julie M. Fenster (Audio Cassette - Jan 8, 2008)

27. The Myth of Alzheimer's: What You Aren't Being Told About Today's Most Dreaded Diagnosis
by Peter J. Whitehouse and Daniel George (Hardcover - Jan 8, 2008)

28. Inheritance in Contemporary America: The Social Dimensions of Giving across Generations
by Jacqueline L. Angel (Hardcover - Jan 4, 2008)

29. Human Aging (2nd Edition) (MyDevelopmentKit Series)
by Paul W. Foos and M. Cherie Clark (Hardcover - Jan 1, 2008)

30. The End-of-life Handbook: A Compassionate Guide to Connecting With and Caring for a Dying Loved One
by David B. Feldman, Stephen Andrew Lasher Jr., and Ira Byock (Paperback - Jan 3, 2008)

31. The 30-Minute Celebrity Makeover Miracle: Achieve the Body You've Always Wanted
by Steve Zim and Steve Steinberg (Hardcover - Jan 2, 2008)

32. American Medical Association Guide to Preventing and Treating Heart Disease: Essential Information You and Your Family Need to Know about Having a Healthy Heart
by American Medical Association, Martin S., MD Lipsky, Marla, MD Medelson, and Stephen, MD, MPH Havas (Hardcover - Jan 2, 2008)

33. Changing Course: Navigating Life after Fifty
by William A. Sadler, Ph.D. and James H. Krefft, and Ph.D. (Perfect Paperback - Jan 2, 2008)

34. Have the Time of Your Life in Retirement: The Help-Yourself Guide for a Fun, Fulfilling Retirement
by Dave Brazier (Paperback - Jan 2, 2008)

35. How Not to Look Old: Fast and Effortless Ways to Look 10 Years Younger, 10 Pounds Lighter, 10 Times Better
by Charla Krupp (Hardcover - Jan 2, 2008)

36. Pet Loss and Human Bereavement
by William Kay, Herbert Nieburg, Austin Kutscher, and Ross Grey (Paperback - Jan 2, 2008)

37. The Relief of Imperfection: For Women Who Try Too Hard to Make It All Just Right
by Joan C. Webb (Paperback - Jan 2, 2008)

38. The Age of Miracles: Embracing the New Midlife
by Marianne Williamson (Hardcover - Jan 1, 2008)

39. Ageless Memory: Secrets for Keeping Your Mind Young Forever - From the World's Foremost Memory Expert
by Harry Lorayne (Hardcover - Jan 1, 2008)

40. Alternative Medicine?: A History
by Roberta Bivins (Hardcover - Jan 1, 2008)

41. Naomi's Guide to Aging Gratefully: Facts, Myths, and Good News for Boomers
by Naomi Judd (Paperback - Jan 1, 2008)

42. The Caregiver: A Life With Alzheimer's (The Culture and Politics of Health Care Work)
by Aaron Alterra and Arthur Kleinman (Paperback - Jan 2008)

43. Oxidation: The Cornerstone of Carcinogenesis: Oxidation and tobacco smoke carcinogenesis. A relationship between cause and effect
by John C. Stavridis (Hardcover - Jan 2008)

44. Sunbelt Retirement: The Complete State-By-State Guide to Retiring in the South and West of the United States
by Peter A. Dickinson (Hardcover - Jan 2008)

45. Ten Years Thinner
by Christine Lydon (Hardcover - Jan 2008)

46. Immunosenescence (Medical Intelligence Unit)
by Graham Pawelec (Hardcover - Jan 2008)

47. Textbook of Men's Health and Aging, Second Edition
by Bruno Lunenfeld, Louis J.G. Gooren, Alvaro Morales, and John E. Morley (Hardcover - Dec 26, 2007)

48. Foods That Combat Aging: The Nutritional Way to Stay Healthy Longer
by Deborah Mitchell (Mass Market Paperback - Dec 26, 2007)

49. Medical Decisions, Estrogen and Aging
by Jay Schulkin (Hardcover - Dec 21, 2007)

50. The Official Anti-aging Revolution: Stop the Clock, Time is on Your Side for a Younger, Stronger, Happier You
by Ronald, M.D. Klatz and Robert, M.D., Ph.D. Goldman (Paperback - Dec 20, 2007)

51. Lecture Notes: Elderly Care Medicine (Lecture Notes)
by Claire Nicholl, Jane Wilson, and Stephen Webster (Paperback - Dec 19, 2007)


The same list is repeated below in enhanced version with book images added:

-----------------

Enhanced List with Book Images Provided (where they are available)


1.
Living Long and Loving It: Achieving a Healthy and Active Lifestyle
by Irvin M. Korr and Rene J. McGovern (Paperback - Jan 31, 2008)


2.
Survival: The Survival of the Human Race (Darwin College Lectures)
by Emily Shuckburgh (Paperback - Jan 31, 2008)


3.
microRNAs: From Basic Science to Disease Biology
by Sidney Altman, Victor R. Ambros, and Krishnarao Appasani (Hardcover - Jan 31, 2008)


4.
Essentials of Geriatric Physical Therapy
by Jennifer M., Ph.D. Bottomley (Hardcover - Jan 31, 2008)

5.
Blood Disorders in the Elderly
by Lodovico Balducci, William Ershler, and Giovanni de Gaetano (Hardcover - Jan 31, 2008)


6.
Beat Memory Loss: The Complete Guide to Making the Most of Your Memory (Use Your Brain to Beat... S.)
by Rita Carter (Paperback - Jan 30, 2008)


7.
Eternal Puppy: Keeping Your Dog Young Forever
by Janice Willard and Marty Becker (Paperback - Jan 30, 2008)


8.
The Myth of Generational Conflict: The Family and State in Ageing Societies
by Sara Arber (Paperback - Jan 30, 2008)

9.
Continence Care (Essential Clinical Skills for Nurses)
by Florence Mitchell (Paperback - Jan 30, 2008)


10.
Smile for Life: Rejuvenation Dentistry and the Art of Wellness
by Gerald P. Curatola (Paperback - Jan 30, 2008)


11.
Fatty Acid and Lipotoxicity in Obesity and Diabetes (Novartis Foundation Symposia)
by Novartis Foundation (Hardcover - Jan 28, 2008)


12.
You and Your Aging Parent: A Family Guide to Emotional, Social, Health, and Financial Problems
by Barbara Silverstone and Helen Kandel Hyman (Paperback - Jan 28, 2008)


13.
Tales of Graceful Aging from the Planet Denial (Thorndike Press Large Print Nonfiction Series)
by Nicole Hollander (Hardcover - Jan 22, 2008) - Large Print


14.
Ultra-Longevity: The Seven-step Program for a Younger, Healthier You (Thorndike Large Print Health, Home and Learning)
by Mark Liponis (Hardcover - Jan 22, 2008) - Large Print


15.
You, Staying Young: The Owner's Manual for Extending Your Warranty (Thorndike Large Print Health, Home and Learning)
by Mehmet, M.D. Oz and Michael F., M.D. Roizen (Hardcover - Jan 22, 2008) - Large Print

16.
Social Policy in Ageing Societies: Britain and Germany Compared
by Gerhard Naegele and Alan Walker (Hardcover - Jan 22, 2008)

17.
Reverse Heart Disease Now: Stop Deadly Cardiovascular Plaque Before It's Too Late
by Sinatra, James C., M.D. Roberts, and Martin Zucker (Paperback - Jan 18, 2008)


18.
Adult Development and Aging
by Paul A Roodin and William J. Hoyer (Hardcover - Jan 15, 2008)

19.
From Belly Fat to Belly Flat: How Your Hormones Are Adding Inches to Your Waist and Subtracting Years from Your Life -- the Medically Proven Way to Reset Your Metabolism and Reshape Your Body
by M.D., C.W. Randolph and Genie James (Paperback - Jan 15, 2008)


20.
The Healthy Seniors Cookbook: Ideal Meals and Menus for People Over Sixty (Or Any Age)
by Marilyn McFarlane and Carol Baird (Paperback - Jan 15, 2008)


21.
Senior Days: Insightful Tales and No-Nonsense Help from the Frontlines of Eldercare
by Colleen Nicol (Paperback - Jan 15, 2008)


22.
Healthy Aging and Longevity: Third International Conference (Annals of the New York Academy of Sciences)
by Noah J. Weller and Suresh I. S. Rattan (Paperback - Jan 14, 2008)


23.
The Natural Hormone Makeover: 10 Steps to Rejuvenate Your Health and Rediscover Your Inner Glow
by Phuli Cohan (Hardcover - Jan 14, 2008)


24.
The Vitamin D Cure
by James Dowd and Diane Stafford (Hardcover - Jan 14, 2008)


25.
Healthy Aging For Dummies (For Dummies (Health & Fitness))
by Brent Agin and Sharon, RN Perkins (Paperback - Jan 10, 2008)


26.
The Myth of Alzheimer's: The Story of a Disease, a Doctor, and a New Direction for Aging in the 21st Century
by Whitehouse M.d., Peter J. ph.d, Danny George, and Julie M. Fenster (Audio Cassette - Jan 8, 2008)


27.
The Myth of Alzheimer's: What You Aren't Being Told About Today's Most Dreaded Diagnosis
by Peter J. Whitehouse and Daniel George (Hardcover - Jan 8, 2008)


28.
Inheritance in Contemporary America: The Social Dimensions of Giving across Generations
by Jacqueline L. Angel (Hardcover - Jan 4, 2008)


29.
Human Aging (2nd Edition) (MyDevelopmentKit Series)
by Paul W. Foos and M. Cherie Clark (Hardcover - Jan 1, 2008)


30.
The End-of-life Handbook: A Compassionate Guide to Connecting With and Caring for a Dying Loved One
by David B. Feldman, Stephen Andrew Lasher Jr., and Ira Byock (Paperback - Jan 3, 2008)


31.
The 30-Minute Celebrity Makeover Miracle: Achieve the Body You've Always Wanted
by Steve Zim and Steve Steinberg (Hardcover - Jan 2, 2008)


32.
American Medical Association Guide to Preventing and Treating Heart Disease: Essential Information You and Your Family Need to Know about Having a Healthy Heart
by American Medical Association, Martin S., MD Lipsky, Marla, MD Medelson, and Stephen, MD, MPH Havas (Hardcover - Jan 2, 2008)


33.
Changing Course: Navigating Life after Fifty
by William A. Sadler, Ph.D. and James H. Krefft, and Ph.D. (Perfect Paperback - Jan 2, 2008)


34.
Have the Time of Your Life in Retirement: The Help-Yourself Guide for a Fun, Fulfilling Retirement
by Dave Brazier (Paperback - Jan 2, 2008)


35.
How Not to Look Old: Fast and Effortless Ways to Look 10 Years Younger, 10 Pounds Lighter, 10 Times Better
by Charla Krupp (Hardcover - Jan 2, 2008)


36.
Pet Loss and Human Bereavement
by William Kay, Herbert Nieburg, Austin Kutscher, and Ross Grey (Paperback - Jan 2, 2008)


37.
The Relief of Imperfection: For Women Who Try Too Hard to Make It All Just Right
by Joan C. Webb (Paperback - Jan 2, 2008)


38.
The Age of Miracles: Embracing the New Midlife
by Marianne Williamson (Hardcover - Jan 1, 2008)


39.
Ageless Memory: Secrets for Keeping Your Mind Young Forever - From the World's Foremost Memory Expert
by Harry Lorayne (Hardcover - Jan 1, 2008)


40.
Alternative Medicine?: A History
by Roberta Bivins (Hardcover - Jan 1, 2008)


41.
Naomi's Guide to Aging Gratefully: Facts, Myths, and Good News for Boomers
by Naomi Judd (Paperback - Jan 1, 2008)


42.
The Caregiver: A Life With Alzheimer's (The Culture and Politics of Health Care Work)
by Aaron Alterra and Arthur Kleinman (Paperback - Jan 2008)


43.
Oxidation: The Cornerstone of Carcinogenesis: Oxidation and tobacco smoke carcinogenesis. A relationship between cause and effect
by John C. Stavridis (Hardcover - Jan 2008)


44.
Sunbelt Retirement: The Complete State-By-State Guide to Retiring in the South and West of the United States
by Peter A. Dickinson (Hardcover - Jan 2008)

45.
Ten Years Thinner
by Christine Lydon (Hardcover - Jan 2008)


46.
Immunosenescence (Medical Intelligence Unit)
by Graham Pawelec (Hardcover - Jan 2008)


47.
Textbook of Men's Health and Aging, Second Edition
by Bruno Lunenfeld, Louis J.G. Gooren, Alvaro Morales, and John E. Morley (Hardcover - Dec 26, 2007)


48.
Foods That Combat Aging: The Nutritional Way to Stay Healthy Longer
by Deborah Mitchell (Mass Market Paperback - Dec 26, 2007)


49.
Medical Decisions, Estrogen and Aging
by Jay Schulkin (Hardcover - Dec 21, 2007)


50.
The Official Anti-aging Revolution: Stop the Clock, Time is on Your Side for a Younger, Stronger, Happier You
by Ronald, M.D. Klatz and Robert, M.D., Ph.D. Goldman (Paperback - Dec 20, 2007)

51.
Lecture Notes: Elderly Care Medicine (Lecture Notes)
by Claire Nicholl, Jane Wilson, and Stephen Webster (Paperback - Dec 19, 2007)


If you do know some new books that should be added to this list, please feel free to add them here!

Key words:
New books, aging, ageing, longevity, gerontology, gerontological, geriatrics, geriatric, senescence, anti-aging, anti-ageing, rejuvenation, life-extension, immortality


Home:
Longevity Science Blog
and
New Books on Aging, Longevity, Gerontology, Geriatrics, Life-Extension & Anti-Aging Interventions
Shorter weblink:
http://tinyurl.com/35s4n4

.