Friday, January 26, 2007


SENS stands for
Strategies for Engineered Negligible Senescence
scientific initiative

See also:
What is Aging? Anti-Aging Is Immortality Possible?

To Read comments on this topic and post your own thoughts, click here


Recently Steve Connor, the science editor of 'The Independent' has published an interesting review of a new popular book "How to Live Forever or Die Trying", by Bryan Appleyard.

The review is critical, which is understandable for evaluations of a popular book, but I am struck by the following comment about the life-extension researcher, Dr. Aubrey de Grey:

"... de Grey's belief in immortality - or "strategies for engineered negligible senescence" - are something of a laughing-stock among mainstream gerontologists"

Well, all you need to do is just to take a look at this scientific book below, which contains research publications by over a hundred of mainstream gerontologists, with Dr. Aubrey de Grey being a Scientific Editor (!):

Strategies for Engineered Negligible Senescence:
Why Genuine Control of Aging May Be Foreseeable
(Annals of the New York Academy of Sciences)

Obviously, the "strategies for engineered negligible senescence" (SENS) are not a laughing-stock any longer among mainstream gerontologists, and many of them do participate in this scientific initiative.

Also read the relevant consensus letter "Antiaging Technology and Pseudoscience" signed by seven experts and published in Science, which acknowledges the legitimacy of anti-aging studies and cites the list of these anti-aging scientific publications. Please note that the first author of this published consensus letter is Dr. Aubrey de Grey.
This Science letter was later cited in a prestigious 2003 Macmillan Encyclopedia of Population, USA with a comment: "...the possibility should not be excluded that current intensive biomedical anti-aging studies may help to extend the healthy and productive period of human life in the future (de Grey et al., 2002)."

My personal attitude to the SENS scientific initiative could be best characterized with a quote by George Bernard Shaw (1856-1950):

"The reasonable man adapts himself to the world;

the unreasonable one persists in trying to adapt the world to himself."

"Therefore, all progress depends on the unreasonable man."

See also: New Books Discussing SENS

Disclaimer for a potential conflict of interest
We have published three articles in this SENS book, so we do know what we are talking about:

Gavrilov LA, Gavrilova NS. Early-Life Programming of Aging and Longevity: The Idea of High Initial Damage Load (the HIDL Hypothesis). Annals of the New York Academy of Sciences, 2004, 1019: 496-501.

Gavrilova NS, Gavrilov LA, Semyonova VG, Evdokushkina GN. Does Exceptional Human Longevity Come With High Cost of Infertility? Testing the Evolutionary Theories of Aging. Annals of the New York Academy of Sciences, 2004, 1019: 513-517.

Gavrilov LA, Gavrilova NS. The Reliability-Engineering Approach to the Problem of Biological Aging. Annals of the New York Academy of Sciences, 2004,
1019: 509-512.

Also I have to admit that I am one of seven coauthors of the above mentioned consensus letter "Antiaging Technology and Pseudoscience" published in Science.

See also:
What is Aging? Theories of Aging Anti-Aging Population Aging

Read further comments, and post your own thoughts here

Labels: , ,


Anonymous Anonymous said...

There is quite a lot of superheated rhetoric being posted about SENS. SENS is undeniably highly optimistic and may or may not be realistic. Many think it too optimistic, and worry that it will hurt the science of gerontology.

But, Aubrey has already raised more than one million dollars for gerontological research with his optimism. This money might never have been available if he had not started SENS. He has captured the imagination of some people. Pessimism and criticism (even if you think it is realism) rarely raises money, captures the imagination of successful people, or accomplishes much which is positive.

-- Steve Spindler, Ph.D.,
Professor of Biochemistry,
Department of Biochemistry,
University of California, Riverside, CA

1:13 PM  
Anonymous Anonymous said...

Heresies should be encouraged, even if they merely make those doing more conventional work – the vast majority in most fields - think more broadly. It’s astonishing how reluctant many researchers are even to contemplate innovative ideas, especially if the person is an outsider from a different field, unless the ideas directly bolster their own work. Have they forgotten how often such creative people are proved correct, years after their ideas have been derided or ignored, and have they forgotten Crick, and Perutz – two amongst the many outsiders - physicists - who trod indelicately, but oh so fruitfully, in the field that subsequently developed as molecular biology? Aubrey might not be proved right or wrong until well after we’re all dead, but it’s excellent that he has brought a breath of fresh air (as well as funding), into ageing research.

Professor Ruth Itzhaki
Faculty of Life Sciences
University of Manchester
United Kingdom

5:55 PM  
Blogger bmahfood said...

Thanks for stopping by my blog! I will keep checking yours for more great info on SENS.

Barry's Best Blog -
The Price of Rice! -

12:03 PM  
Blogger Unknown said...

Thanks for pointing out this post and your blog to me.

Wonderful to learn what's happening at the frontier of science and to read the opinion of informed researchers in the comments too!


11:41 PM  
Anonymous Anonymous said...

Although I understand your emotions, I'd suggest that instead of being touchy you should accept the criticism as a part of life in a competitive society (at the level of mere opinion there are no winners) and take a more pragmatic approach. What part of your vast knowledge is applicable to your everyday life? At the end the day the decision whether your theories are useful will be at the level of the individual. I'll be interested to learn as to how you translate your knowledge into practice.

3:01 PM  
Blogger ---vertovis said...

Thank you for alerting me to your blog and all the interesting info herein.

12:37 PM  
Blogger Peggy K said...

Thanks for stopping by my blog and suggesting I stop by here.

I suspect that part of the problem is that the popular press tends to focus on the more speculative of deGrey's ideas (which don't seem to be based in particularly solid biology). His ideas seem to have attracted a fair number of "disciples" that really don't understand the science and take de Grey's most fantastic claims (e.g. the first person to live for 1000 years was born in 1945) as gospel. It doesn't help that he is extremely confident in his ideas, outspoken, as well as a bit of an odd fellow.

The circus around SENS overshadows the solid (but non-flashy) research on longevity that is indeed supported by de Grey and his Methuselah Foundation. I'm reminded a bit of the hoopla surrounding the human genome project, including some over-the-top claims as to what the outcome of the project would mean to medicine and science in the short term. That doesn't mean it wasn't an important scientific endeavor, and the hype probably did help in getting it funded.

(I have several links about de Grey and his ideas from MIT's Technology Review and other sources in a post on my blog, if people are interested.)

5:13 PM  
Anonymous Anonymous said...


Great work!!

I found this useful blog also quite useful with videos, links and explanations about Fitness & Health & Anti-Aging & Life Extension:



10:14 AM  
Blogger Unknown said...

Hi Leonid,

On balance, given the benefits of real anti-aging therapies and the fact that serious scientists are working towards them and discuss their possibility, I think skepticism that they can be developed at all will soon be more appropriately applied to how to make the fastest progress.

That will be a huge step forward and hearing this message from respected gerontologists and other researchers will hasten that transformation.

Thanks for this great post.

Kevin Perrott
Executive Director
The Mprize

2:55 AM  
Anonymous Anonymous said...

Thank you for your interesting comments!

See also:

New Books Discussing SENS

1:11 PM  
Anonymous Anonymous said...

One of the most common flaws found within the human race, is its lack of cooperation as a whole. If it were at all possible to cooperate, we could potentially solve one of life's most basic problems.
But alas, this complex organism (humans) will never learn to cooperate as a whole on this mud ball, which floats in the void of space.

2:34 AM  
Anonymous Theodore A. Hoppe said...

While we may want to live longer the quality of life is a corollary issue. There is a short 4 minute talk by Gregory Petsko that warns of the coming neurological epidemic. Mr. Pescko states: The average lifespan more than doubled since 1840, and it increasing currently at the rate of about five hours every day. And this is why that's not entirely a good thing: because over the age of 65, your risk of getting Alzheimer or Parkinson Disease will increase exponentially. By 2050, there will be about 32 million people in the United States over the age of 80, and unless we do something about it, half of them will have Alzheimer Disease and three million more will have Parkinson Disease." We currently have no cure or prevention for these or other neurological diseases. His brief talk is must viewing to those interested in this topic.

9:12 PM  
Anonymous Anonymous said...

You posted an interesting and somewhat inspiring quote by the late George Bernard Shaw:

"The reasonable man adapts himself to the world;

the unreasonable one persists in trying to adapt the world to himself."

"Therefore, all progress depends on the unreasonable man."

While I am not always considered reasonable, it seems anything but reasonable to allow death on a voluntary basis. That being said, I don't see the neccessity in adapting the world to ourselves in such circumstance(as it relates to the quote). What does seem obvious, is the conclusion that survival in its purest and most unadulterated form is the greatest proof of man's adaptation to the world. Therefore, one can logically deduce that "the reasonable man" shall be the one in pursuit of life in and of itself, and therefore, with the aforementioned onslaught of future technologies at his disposal, shall have the higher probability of acheiving progress in such circumstance. The unreasonable man shall find no reason in which any such ideas(or subset thereof) shall come to fruition.

8:14 PM  
Blogger Jones Morris said...

Thanks for posting this info. I just want to let you know that I just check out your site and I find it very interesting and informative. I can't wait to read lots of your posts. jason hope

2:48 PM  
Blogger Unknown said...

cheap toms
timberland boots
oakley outlet
beats by dre outlet
jordan retro 13
air jordan shoes
lebron james shoes 13
true religion outlet
nike running shoes for men
north face jackets
tiffany and co jewelry
longchamp outlet
gucci outlet online
louis vuitton bags
michael kors outlet
louis vuitton purses
ray ban outlet
nike store uk
coach factory outlet online
coach outlet
true religion outlet
kd 8
michael kors handbags
tiffany and co
cheap jordans
rolex watches
cheap jordan shoes
tods sale
michael kors outlet
nfl jerseys
coach factory outlet online
adidas superstar
michael kors outlet
adidas originals
oakley outlet
coach outlet store
cheap oakleys
cheap air jordans
coach outlet
coach outlet

2:06 AM  
Blogger Unknown said...

See if your instagram account hacked
how to hack whatsapp online

9:14 AM  
Blogger Unknown said...


1:31 PM  
Blogger crackstools said...

Cracks software Download
Cracks software Download
Cracks software Download
Cracks software Download
Cracks software Download
Cracks software Download
Cracks software Download
Cracks software Download
Cracks software Download
Cracks software Download

12:08 AM  
Blogger crackstools said...

Your website content is very effective and help full for people.I understood that you try to clear that concept about this subject.But i also read another content from another website. I think it's most better full content to your website content.So i suggest you, if you have a time to on your hand you will try to visit this website.Cracks software Download

12:10 AM  
Blogger crackstools said...

Soft Crack Activator,Product keys, patch, keygen all in one site

12:12 AM  
Blogger Cracktaking said...

cracktaking is trusted source of all premium crack software, Serial Keys, Patches, Activators, Key gens, For all your devices Android, MAC, Windows. Cracktaking has a Great collection of all your Daily use Cracks Tools.

8:22 PM  
Blogger Cracktaking said...

cracktaking is trusted source of all premium crack software, Serial Keys, Patches, Activators, Key gens, For all your devices Android, MAC, Windows. Cracktaking has a Great collection of all your Daily use Cracks Tools.

8:55 PM  
Anonymous Cara Ampuh Menyuburkan Kandungan said...

Herbal treatment can be carried out effectively and without side effects. Thank you for sharing most information.

Pengobatan Gula Darah Tinggi
Cara Paling Cepat Untuk Melangsingkan Tubuh
Pengobatan Paling Efekti Penyakit Anemia Atau Kurang Darah
Pencegahan Dan Pengobatan Miom Tanpa Efek Samping
Obat Herbal Usus Buntu
Cara Mengatasi Mata Akibat Iritasi Softlens

3:40 AM  
Anonymous Cara menyembuhkan liver said...

given article is very helpful and very useful for my admin, and pardon me permission to share articles here hopefully helped :

Obat infeksi usus
Obat leukosit tinggi
Obat gabagen
Obat herbal penyakit asma
Obat herbal demam berdarah
Obat herbal jantung koroner
Obat herbal tukak lambung

9:14 PM  
Blogger Unknown said...

guess factory
suicoke sandals
bulgari jewelry
canada goose jackets
bcbg dresses
jordan shoes
lakers jerseys
bulls jerseys
tory burch outlet
cheap snapbacks

8:11 PM  
Anonymous Cara menyembuhkan polip hidung said...

thank you very useful information admin, and pardon me permission to share articles here may help :

Nurhasanah herbal
Cara mengatasi tulang keropos
Obat liver sirosis
Cara mengatasi sakit tenggorokan
Cara menyembuhkan tipes
Cara menyembuhkan luka bakar
Obat keloid

4:55 AM  
Blogger Unknown said...

burberry outlet
coach outlet
warriors jerseys
fossil watches
pandora outlet
supra shoes
michael kors outlet
keen shoes
hornets jerseys
ferragamo outlet

7:56 PM  
Anonymous Cara menyembuhkan tumor testis said...

thank you very useful information admin, and pardon me permission to share articles here may help :

Cara mengatasi asam lambung naik ke dada
Obat penurun asam lambung tinggi
Cara mengatasi jerawat meradang
Cara menyembuhkan radang telinga
Obat varises vagina
Obat gabagen bayi
Cara membersihkan flek hitam di wajah

7:30 PM  
Anonymous Obat radang lambung said...

given article is very helpful and very useful for my admin, and pardon me permission to share articles here hopefully helped :

Obat tradisional kanker paru paru
Obat gagal ginjal selain cuci darah
Obat herbal benjolan di kepala
Obat tradisional penyempitan pembuluh darah
Cara mengatasi luka di usus
Cara mengatasi usus yang meradang
Suplemen untuk membakar lemak

7:31 PM  
Blogger Unknown said...

off white clothing
moncler jackets
uggs outlet
yeezy shoes
oakley sunglasses wholesale
ugg boots
michael kors outlet online
canada goose jackets
ultra boost 3.0
ralph lauren uk

3:22 AM  
Blogger Unknown said...


salomom shoes
fitflops sale clearance
canada goose jackets
ecco shoes
nike huarache
off white shoes
nike requin pas cher
ultra boost
true religion outlet

2:58 AM  
Blogger 5200 said...

0824jejeCela nike air jordan 1 retro mid nouveau bhm signifie qu'il y a beaucoup de possibilités pour nike air jordan 1 retro mid north carolina que les rôles de niveau asics gel kinsei 5 homme supérieur soient généralement remplis dans adidas zx flux rouge et noir pas cher cette région. Beaucoup sont venus asics femme nimbus 19 à l'ouest après avoir essayé plusieurs nike air max 1 femme rose et noir vocations. Quelques flammes vont vous lever air jordan 1 retro alpha et fonctionner sans aucune question posée.

8:45 PM  
Blogger zzyytt said...

adidas yeezy
balenciaga shoes
birkin bag
supreme clothing
adidas nmd
hogan outlet online
birkin bag
jordan retro 6
adidas ultra boost uncaged
off white jordan 1

8:10 PM  
Blogger jonet said...

3:56 AM  
Blogger jonet said...

3:56 AM  
Blogger jonet said...

3:57 AM  
Blogger jonet said...

3:57 AM  
Blogger Jisoo Blackpink said...

This article is very useful, thank you for sharing. And allow me to share articles too, it's about health and treatment. God willing it will be useful for us all. Thank you :)

obat jantung bocor
cara mengobati sakit kepala yang tak kunjung sembuh
cara menyembuhkan asma secara total
obat kaki bengkak tradisional
cara mengobati tipes
cara mengobati infeksi lambung secara alami
cara mengobati kanker payudara secara alami

12:43 AM  
Anonymous Obat Sakit Pinggang di Apotik said...

The article is very interesting. And I also want to share articles about health, I'm sure this will be useful. Read and share it. Thank you very much :)

Pengobatan Alternatif TBC Tulang
Cara Penyembuhan Hepatitis B Akut
Manfaat Daun Sirih untuk Keputihan Abnormal

8:06 PM  
Blogger Jisoo Blackpink said...

It is imperative that we read blog post very carefully. I am already done it and find that this post is really amazing.

Agen Resmi QnC Jelly Gamat
obat cacar api tradisional
cara mengobati nyeri dada secara alami
cara mengobati cacar air agar cepat kering
cara mengatasi sesak nafas
obat penghilang lipoma
cara mengobati usus buntu tanpa operasi

12:17 AM  
Blogger Jisoo Blackpink said...

Hello, we are from the health site admin, want to share our latest articles :

obat kanker prostat paling ampuh
cara mengobati batuk rejan secara alami
cara membersihkan paru paru secara alami
obat tradisional bab berdarah
cara mengobati telinga berair dan bau
obat telinga berair paling ampuh dan aman
obat sakit pinggang sebelah kanan tradisional

3:01 AM  
Anonymous Cara Menghilangkan Kelenjar Tiroid said...

Very interesting article, thank you for sharing. I also want to share the following health articles, God willing, useful. Thank you :)

Obat Usus Buntu Tanpa Operasi
Cara Mengatasi Sembelit atau Konstipasi
Obat Iritasi Mata Karena Softlens

10:42 PM  
Anonymous Anonymous said...

1:18 AM  
Blogger devin said...;u=2625618

4:21 AM  
Blogger yanmaneee said...

off white nike
adidas ultra
air jordan
nike air max 2019
nike air max
kyrie 5
supreme hoodie

9:02 PM  
Blogger pat said...

Download and install Vidmate App which is the best HD video downloader software available for Android. Get free latest HD movies, songs, and your favorite TV shows.

3:53 AM  
Blogger vidmate apk said...

Really i found this article more informative, thanks for sharing this article! Also Check here

Download and install Vidmate App which is the best HD video downloader software available for Android. Get free latest HD movies, songs, and your favorite TV shows

Vidmate App Download

Vidmate apk for Android devices

Vidmate App

download Vidmate for Windows PC

download Vidmate for Windows PC Free

Vidmate Download for Windows 10

Download Vidmate for iOS

Download Vidmate for Blackberry

Vidmate For IOS and Blackberry OS

2:11 PM  
Blogger midou midou said...

This article is interesting, if you want to know more visit

our website



6:08 AM  
Blogger yanmaneee said...

golden goose outlet
moncler outlet
supreme hoodie
golden goose sneakers
supreme outlet
golden goose outlet
golden goose outlet

2:09 AM  
Blogger gem1musi said...

دانلود آهنگ جدید
آهنگ شاد رقصیدنی
ریمیکس رادیو جوان
ریمیکس شاد قدیمی
آهنگ تولدت مبارک
آهنگ پرسپولیس
آهنگ رپ خارجی
آهنگ های علی یاسینی
آهنگ شاد عروسی

2:20 PM  
Anonymous Anonymous said...

Hi !
Write only if you are serious! My name is Jess. I am 25.
My fashionable photos and sexy videos here

[b][url=]>>>Click!<<<[/url] [/b]

[url=][IMG] [/IMG] [/url]

dating meaning in bengali
indian dating site free online
best free dating sites in india quora
free dating site usa uk canada
dating discord servers reddit

adult education programs
date movie
free asian dating site
como excluir o dating do facebook
due date


11:50 PM  
Blogger SSD said...

Seks video rape video
Pedofili Porn Video
Hacked Porn Videos
Rape Porn Video

4:23 PM  
Blogger SSD said...

Porn Video

2:15 PM  
Anonymous Anonymous said...


Harjoitellaan Stuntteja [url=]Leffaa[/url] Varten BMA

12:54 PM  
Anonymous Anonymous said...


10 times the Japanese kept the best versions of their [url=]hot[/url] cars for themselves

10:30 AM  
Anonymous Anonymous said...


あいみょん – 今夜このまま 【AIMYON TOUR [url=]2019[/url] -SIXTH SENSE STORY- IN YOKOHAMA ARENA】

10:23 AM  
Anonymous Anonymous said...


Ставим лебедку на УАЗ буханку. Теперь [url=]не[/url] застрянем

4:38 AM  
Anonymous Anonymous said...



3:04 AM  
Anonymous Anonymous said...


Easy [url=]-[/url] Shera Haruwal Full VideoDeep Royce JasmeetLatest Punjabi Song 2020Fame Studioz

10:38 AM  
Anonymous Anonymous said...


Japanese Street Food - GIANT TOP SHELL Sea Snail Okinawa Seafood [url=]Japan[/url]

3:26 PM  

Post a Comment

<< Home