Wednesday, April 11, 2007

Edmonton Aging Symposium

Greetings,

Take a look at interesting presentations given at the recent Edmonton Aging Symposium in Canada, which are now publicly available online here:

The following talk has caught my particular attention:

The Damage of Aging: Present Possibilities and Future Therapies
Huber Warner

This talk argues that the role of damage accumulation in the aging process is probably exaggerated -- particularly for oxidative damage to both nuclear and mitochondrial DNA. This counterintuitive conclusion is based on recent findings that mice defective in superoxide dismutase defence against oxidative damage do NOT live shorter lives, despite observed extensive damage to both nuclear and mitochondrial DNA. Something to think about.

This presentation goes much further, claiming at slide # 9:


Vitamins A, E may be unhealthy
(JAMA 2/28/07 and reported in National Post; March 1, 2007)


This slide also says that Vitamin A increases the risk of death by 16%, and ß-carotene increases the risk of death by 7%.

This is where you have to listen the recorded presentation itself (available at the weblink listed above), to find out that the author himself does not agree with these claims.

So, for each presentation it is better first to download the Power-Point Presentation, then to start the audio of the presentation, and to follow the voice of the speaker clicking the next slides of his Power-Point Presentation.

Interestingly, a similar idea that damage to mitochondrial DNA has still unclear relation to aging was also discussed in another talk:

Mitochondrial DNA Mutations and Their Possible Role in Brain Aging
Konstantin Khrapko

Why additional damage does not always shorten lifespan?
This is indeed a challenge for the evolutionary theories of aging, assuming that “natural selection will always be in greatest opposition to the decline of the most senescence-prone system” and, therefore “senescence should always be a generalized deterioration,'' with all the destruction pathways being equally important.
However this problem can be easily resolved by the reliability theory of aging that emphasizes the existence and the key role of the "weakest links" in system's reliability. If these "weakest links" are not affected, then the damage in other places may have no apparent effects on system's failure.

See also the video of this exciting talk with somewhat intriguing title:

The Color Code and a Rainbow of Health
James Joseph PhD. - Tufts University

This is a rare combination of good science, humorous easy-to-understand presentation with important practical implications for your own health through simple nutrition changes. Dr. James Joseph presented the results of his studies on the effects of a diet high in fruits and vegetables in preventing age-related disease and the impact on behavior with a primary focus the improvement in neurological function and reduction in Alzheimer's symptoms. His lab has shown that blueberry supplementation was able to offset the deleterious consequences on behavior associated with amyloid plaques in mice prone to developing these deposits. The mechanisms by which the active molecules within blueberries are able to increase the generation of new neurons in the brain as well as the pathways by which these molecules help to enhance neuronal signaling and ultimately communication is an area of intense study in Dr. Joseph's lab with results which can potentially be applied to immediately decrease the impact of aging on behavior. Just a short word of caution: it was all done on laboratory animals (rats and mice) only; no similar studies on humans were reported in this presentation.

See also the "Head-to-Head" debates on the Ethics and Desirability of Life-Extension, which is now available here:

These debates are between the advocate of life-extension Gregory Stock and his opponent Daniel Callahan, with Aubrey de Grey as a moderator.

What pleasantly strikes me here is that this contentious issue is discussed during the debates in an academic and very respectful way -- see it yourself!

Very optimistic vision on the economic sustainability of a future life-extension was provided by Ronald Bailey in his talk "Estimating Your Future's Options", see video here.

I wish this talk be longer and more detailed in terms of justification of the optimistic vision for economics of life-extension. Also I feel that even if life-extension is not socially profitable, it still deserves to be pursued, because I believe that human life has its own value, beyond the money dimension.

Overall, these are very interesting and useful records to see and listen.

Please feel free to post your comments on these records below!

Key words:
Edmonton Aging Symposium, Huber Warner, Konstantin Khrapko, James Joseph, Gregory Stock, Daniel Callahan, Aubrey de Grey, Ronald Bailey, life-extension, damage, reliability theory, carotene, DNA, longevity, oxidative damage, risk of death, vitamin A, vitamin E, polyphenolics

Home:
http://longevity-science.blogspot.com/2007/04/edmonton-aging-symposium.html

To read comments on this review, and to post your own thoughts, click here.

Labels: , , , , , , , ,

7 Comments:

Blogger bioimmortality said...

This issue would not be contentious at all if Daniel could cast his mind back to a time when his endocrine and neurotransmitter profile was that of a 20 -25 year-old.

9:10 PM  
Blogger Stanley Shostak said...

dear leonid gavrilov, i am disappointed that sidney wanzer's book, 'to die well: your right to comfort, calm, and choice in the last days of life.' cambridge, ma: a merloyd lawrence book; 2007 has not received the attention it deserves. wanzer raises (indeed, personifies) the vital issue of whether there is a dying process that entitles patients to comfort care as opposed to fighting 'fruitlessly against symptoms that need to be accepted' (27). please consider posting this book and opening a discussion of a dying process. thanx, stanley shostak

9:20 AM  
Blogger aiyipianni said...

Aston Villa rode their luck at Hull City where an 88-minute own goal from Kamil Zayatte saw them leapfrog three points clear of Arsenal and into fourth place in the Premier League wow gold with a 1-0 win.

Villa had to survive Hull penalty wotlk gold appeals for a handball against Ashley Young in time added on, television replays showing that referee Steve Bennett wow gold correctly rejected the claims after consulting a linesman.

Bennett had been involved in controversy after just five minutes when American goalkeeper Brad Friedel looked to have handed Hull the initiative and threaten Villa's return to the Champions League qualifying wow gold zone.

Friedel spilled the ball under pressure from Nick Barmby and stand-in right-back Nigel Reo-Coker turned it into his own net as he attempted to wow gold clear.

But Bennett cut short wow gold celebrations at the KC Stadium -- and let Friedel off the hook -- when he ruled out the score for an wow wotlkapparent infringement by Barmby.

Zayatte's intervention from a Young cross bound for wow gold Gabriel Agbonlahor then saw Villa leapfrog Arsenal and draw level with Manchester United on 38 points -- seven adrift of leaders Liverpool and four wow gold behind Chelsea.

Stung by an on-pitch dressing down wow gold by manager Phil Brown at Manchester City last week, Hull showed five changes and a vastly improved performance.

Promoted Hull were looking for only their second win in 11 games while wow gold Villa arrived unbeaten in seven and it looked to be heading for a goalless draw when the home side suffered a cruel late blow.

8:12 PM  
Blogger aiyipianni said...

Premier League leaders Liverpool thrrew their "full support" world of warcraft gold behind Steven Gerrard after their captain was charged with assault on Tuesday following an incident at a local nightclub.

Gerrard, 28, and two other men were charged with assault occasioning bodily harm and affray, Merseyside police said.

They are scheduled to world of warcraft gold appear in court on January 23.

In the wake of the charges, Liverpool issued a wow power leveling statement on their official Web site.

"Steven has been an outstanding servant to Liverpool for the last ten years and the club will give him all the support he needs at this time," it read.

The offenses with which Gerrard have been charged carry a maximum penalty of five years in prison.

Three other men, who were also arrested, were world of warcraft gold released without charge pending further inquiries.

Gerrard was arrested cheap wow gold in the early hours of Monday morning and eventually charged after over 20 hours in police custody.

His wife Alex Curran was seen near the police station where world of warcraft gold he was held but drove off without talking to reporters.

Gerrard had been celebrating his side's 5-1 buy wow gold win over Newcastle on Sunday when the alleged altercation occurred.

He had scored two goals in the victory at St James' Park which left world of warcraft gold Liverpool top of the English Premier League and on course for their first English title in 18 years.

He was released on bail to wow power leveling appear in court on January 23 with John Doran, 29, and Ian Smith, 19, who were charged with the same offenses.

Gerrard, who has spent his entire career with Liverpool, world of warcraft gold is one of the most celebrated players in the club's history and renowned as a model professional.

In 2005 he lifted the European Cup -- Liverpool's fifth -- wow gold kaufen after a thrilling penalty shooting victory over AC Milan and turned down the advances of cash-rich Chelsea to stay with his local club.

The midfielder has also made 70 appearances for England, captaining his country on four occasions.

He was made an Member of the British Empire (MBE) last year and received an honorary fellowship from Liverpool's John Moores University.

Liverpool's next match is against Preston in the English FA Cup on Saturday, a game Gerrard was due to sit out because of suspension

8:15 PM  
Anonymous buy wow gold said...

When the Wow Gold wolf finally found the wow gold cheap hole in the chimney he crawled cheap wow gold down and KERSPLASH right into that kettle of water and that was cheapest wow gold the end of his troubles with the big bad wolf.
game4power.
The next day the Buy Wow Goldlittle pig invited hisbuy gold wow mother over . She said "You see it is just as mttgamingI told you. The way to get along in the world is to do world of warcraft gold things as well as you can." Fortunately for that little pig, he buy cheap wow gold learned that lesson. And he just agamegold lived happily ever after!.

9:58 AM  
Blogger 梦中林 said...

A slim, wide-eyed mygamegoldwoman almost human in virbanksfeatures eyed agamegold the pair. Her nose was sharp, but very elegant. She had tbcgold a pale, trade4gamebeautiful face the color of ivory, and veryge for hair she wore a wondrous mane of downy feathers. Her gown fluttered as she walked—on two delicate worldofgolds but still sharply-taloned feet. “Awake, awake you are,” she said with a pvp365 slight frown. “You should rest, rest.” Krasus bowed to her. “I am ezmmorpg grateful for your ighey hospitality, mistress, but I am well enough to continue on9a9z now.” She cocked her head as a bird might, giving the mageltk365 a reproving look. “No, no…too soon, toogold4guild soon. Please, sit.” The duo looked around u4game and discovered that two chairs, made in the same ready4game fashion as the nest, waited behind happygolds them. Malfurion waited for Krasus, who finally nodded and sat.

9:00 AM  
Anonymous World of Warcraft Gold Guides said...

good post :)

2:36 PM  

Post a Comment

Links to this post:

Create a Link

<< Home