Tuesday, March 20, 2007

Evolution of Aging

Discussion of a new book The Evolution of Aging by Theodore C. Goldsmith


Greetings,

Here is a new book for discussion:

The Evolution of Aging
How New Theories Will Change the Future of Medicine
by Theodore C. Goldsmith


Book Description
Why do we age? Scientists have been baffled by this question for centuries and disagree regarding even the general nature of aging. Is aging the result of fundamental limitations that apply to all living things, or are organisms designed by nature to age because a limited life span conveys some advantage? All of the theories either fail to fully explain observed animal characteristics or conflict with generally accepted evolution theory.
This issue has potentially enormous implications for medicine. If aging is the result of fundamental and unalterable forces of nature, then anti-aging medicine is impossible and anti-aging research is futile and foolish. If aging is imposed by an evolved life span regulation system, then research will likely reveal means for altering the operation of the aging mechanism and thereby improve the treatment of many age-related diseases and conditions.
This book provides a historical review of biological aging theories including underlying evolution and genetics issues and describes exciting recent discoveries and new theories that are causing renewed interest in aging-by-design. The author discusses Darwin's theory of evolution as well as more recent proposed modifications such as the selfish gene theory, evolvability theory, and group selection in connection with their effects on aging theory. A chapter is devoted to describing the aspects of modern genetics that have implications for evolution theory including the application of digital information theory to genetics.

Comment
This book looks like a popular book (with 29 references only) promoting a controversial idea that aging is genetically programmed. The search for author's scientific publications in peer-reviewed mainstream scientific journals through Pubmed/Medline returns only one article published by this author in Medical Hypotheses, 2004;62(2):304-8: "Aging as an evolved characteristic - Weismann's theory reconsidered." It looks like the author is not an evolutionary biologist, but rather an expert in computer programming, digital systems engineering and microcircuit design for NASA projects (as described at the back cover of the book).
Overall, the book contains some new interesting ideas, but it is definitely not a recommended mainstream textbook for students.
On the other hand, after reading this book, I believe it could be recommended as an additional reading, stimulating creative thinking.



Excerpts:

Page 48 (Disposable Soma Theory):
In fact, some traditional biologists such as Leonid Gavrilov, of the Center on Aging at the University of Chicago, consider the disposable soma theory to be a "version of" the antagonistic pleiotropy theory and a "widowed concept" [Note: what is missing here is the reference to original publication, which explains why the Disposable Soma Theory is a version of the antagonistic pleiotropy theory, and how it has become a "widowed concept"]

Page 153 (Anti-Aging Research):
It is therefore apparent that solutions to the question "what causes aging" may be as unlikely to come from evolutionary biology alone in the next 140 years, as they have been in the previous 140 years. Even some traditional biologists such as L. Gavrilov (26) caution against basing research decisions on theories to an excessive extent:
"Now, when the single-gene life-extending mutations have been found, evolutionary biologists are presented with the task of reconciling these new discoveries with the [traditional] evolutionary theory of aging, and no doubt they will ultimately succeed. However, gerontologists will also have to learn a lesson from the damage caused by decades of misguided research, when the search for major life-extending mutations and other life-extension interventions was equated by evolutionary biologists to a construction of perpetual motion machine."
Future medical researchers tend to be unaware of this history when learning in "Biology 101" about "generally accepted theories of aging." [Note: I agree].

Post your comments below!:

Labels: , , , , , , , ,

5 Comments:

Blogger Arunabh said...

Aging could be a evolutionary process to reduce the competition within the species.

1:05 AM  
Anonymous GeneBean said...

From the publisher of The Evolution of Aging by Theodore C. Goldsmith, ISBN 0978870905.

Aging appears to be a radically different phenomenon depending on one’s point of view. For physicians, medical researchers, and others very familiar with human aging, the overwhelming impression is that aging results from a fundamental deteriorative process. Members of this group tend to believe in aging theories that involve entropy, accumulation of molecular damage, or other processes similar to those that cause aging in mechanical or chemical systems. They also consequently tend to believe that aging, per se, is unalterable. We can devise treatments for individual manifestations of aging but there is no possible generic “anti-aging” treatment because of the fundamental nature of aging.

For a much smaller group consisting of zoologists and other science-adept people highly familiar with life-cycle characteristics of many non-human species, the overwhelming impression is that organisms are designed to have a limited and species-specific life span. Believers in aging-by-design tend to be much more optimistic regarding the possibility of anti-aging medicine. After all, most pharmaceuticals are intended to alter or compensate for some aspect of human design. However, there is a major problem that appeared in 1859: The mechanics aspect of Darwin’s evolution theory (survival of the fittest) is incompatible with evolution of a design feature that limits life span. Efforts spanning nearly 150 years have been unsuccessful in developing a theory of aging that successfully explains the multi-species observations within Darwin’s mechanics.

Goldsmith, trained as a digital systems engineer and therefore an outsider to both theory groups, chronicles the development of the competing theories and presents extensive evidence suggesting that aging-by-design is the most credible. The book also catalogs other observed discrepancies with Darwinian mechanics as well as various evolution concepts that have been developed to adjust Darwinism to accommodate them (including aging-by-design).

Goldsmith’s scientific interest is in using modern digital data theory to analyze the evolutionary implications of the digital nature of inheritance. (Genetic codes and the duplication and transfer of digital genetic data during inheritance must follow the general rules pertaining to any digital system.) This work has exposed some additional discrepancies with traditional evolution theory and therefore indirectly strengthened the case for aging-by-design.

11:57 AM  
Blogger Basie said...

I think ageing, evolution and inbreeding prevention is closely related.
Have a look at the website at:

www.agingtheory.com

9:25 PM  
Anonymous Anonymous said...

wow gold
wow gold
wow power leveling
wow power leveling
wow gold@@@@
World of Warcraft Gold
wow power leveling
wow power leveling
wow power leveling
wow power leveling
wow power leveling
wow power leveling
wow power leveling
wow power leveling
wow power leveling
wow powerleveling
wow powerleveling
wow powerleveling
rolex replica
wow powerleveling
wow powerleveling
wow powerleveling
wow powerleveling
wow powerleveling
wow powerleveling
wow powerleveling
wow powerleveling
replica rolex
powerleveling
powerleveling
powerleveling
powerleveling
power leveling
power leveling
powerleveling
powerleveling
power leveling
power leveling
power leveling
power leveling
power leveling
power leveling
power leveling
power leveling
rolex
wow gold
wow gold
Warcraft Gold
Warcraft Gold

中高年 転職
アルバイト 求人情報
ブライダル
転職
競馬
FX
ダイエット
お見合い
競馬 予想
新築マンション
新築マンション
コンタクトレンズ
婚約指輪
合宿免許
人材派遣
東京都 墓地
派遣会社
人材派遣
パチンコ 攻略
おなら

货架
OCR
OCR
手机词典
高速扫描
机票
灭蟑螂
蜗轮减速机
减速机
齿轮减速机
丝杆升降机
租房
租房
北京租房
北京租房
搬家公司
北京搬家
北京搬家公司
上海机票
上海机票
上海打折机票
上海打折机票
上海特价机票
上海特价机票
搬家公司
搬家公司
北京搬家公司
北京搬家公司

dgdfgfdhf

8:56 AM  
Anonymous Anonymous said...


telefon tarife karşılaştırma
en uygun tarife
en iyi tarife
en ucuz telefon tarifesi
en uygun tarife
havalandırma
gizli kamera
izolasyon
çelik baca
paslanmaz çelik baca
doğalgaz bacası
Sohbet
telefon tarife karşılaştırma
en uygun tarife
en iyi tarife
en ucuz telefon tarifesi
iso 9001
iso 14001
Yangın Söndürme
yangın söndürme cihazları
yangın dolapları
yangın tüpü
indir
izalasyon
ısıtma soğutma
isitma sogutma
Aspirator
Aspiratör
Vantilatör
sohbetim
turizm işletme belgesi
turizm belgesi
turizm yatırım belgesi
Chat
sohbet odası
sohbet sitesi
türkiye sohbet
tr sohbet
tüm türkiye sohbet
arkadaş sohbet
türkiye sohpet
kızlarla sohbet
kızlarla sohpet
muhabbet
muhappet
kızlarla çet
çet
Gizli Kamera
türkiye çet
çet sohpet
mırç
mirç
türkiye mirc
mirc
muhabbet
Sohbet Sitesi
Chat
Sohpet
Yangın
yangın güvenlik
yangın söndürme sistemleri
yangın tüpü dolum
yangın merdiveni
yangın çıkış kapısı 
Hava Soğutma
Hücreli Aspiratörler
Fanlar
Radyal Körükler
Toz Toplama
Soğutma Kulesi
Klima Santraller
Malzeme Nakil Vantilatörleri
iso 14001
iso 14001
iso 22000
iso 22000
haccp belgesi
haccp belgesi
ikamet tezkeresi
yabancı çalışma izni
yabancı personel çalışma izni
yabancı çalışma izni
yabancı personel çalışma izni
ohsas 18001
ohsas 18001
iso belgesi
iso 9001 belgesi
ohsas belgesi
ISO 9001
Teşvik Belgesi
Çocuk Bezi
Hasta Bezi
Makyaj Malzemeleri
Makyaj Temizleme Mendili
Kişisel Bakım
kolonyalı mendil
Islak mendil
Dudak Koruyucu
Temizlik Ürünleri
Göz Kalemi
Diyet Ürünleri
Süper Site
driver
Güvenlik Kamerası
Islak Mendil
Kolonyalı Mendil
Kolonyalı Mendil
JoyTurk
driver ara
web tasarım
Güvenlik Kamerası
paketleme
Kamera
Kamera Kurulum
Tatil
Tatil Köyleri
Turk tourizm
Turkish tourizm
Turk holiday
Turkish holiday
Turkish travels
Turk Travels
Tatil Yerleri
Tatil Beldeleri
Perde
Perde Modelleri
Kamera
Epilasyon
Emlak
Yaşam
Tatil
Video
Cilt Bakımı
video
süper
perde
jaluzi perde
stor perde
dikey perde
perde modelleri
perde
jaluzi perde
stor perde
dikey perde
perde modelleri
magazin
haberler
spor haberleri
video
eğitim
Giyim
guanzo - çin

4:30 AM  

Post a Comment

Links to this post:

Create a Link

<< Home