Centenarians

List of studies on exceptional human longevity
Corrections and additions are most welcome!


Study title: The Utah Study of Fertility, Longevity and Aging (FLAG)
Principal Investigator: Smith, K.R.
Sample description: Individuals with extreme longevity and their family members recorded in the Utah Population Database
Estimated number of centenarians: ~3,000 born before 1908; ~600 born in 1890-1899


Study title: The New England Centenarian Study
Principal Investigator: Perls, T.T.
Sample description: A population-based sample of individuals achieving exceptional longevity, and living in Massachusetts and Connecticut.
Estimated number of centenarians: 1,500-2,500


Study title: Clinical and Pathological Studies in the Oldest Old
Principal Investigator: Kawas, C.H.
Sample description: Medical history and lifestyle information for 4,682 cohort members who reached age 90 (Leisure World Cohort Study)
Estimated number of centenarians: <500


Study title: Ashkenazi Jewish Centenarian Study
Principal Investigator: Barzilai, N. J.
Sample description: A group of Ashkenazi Jewish centenarians and their children.
Estimated number of centenarians: <500


Study title: Population Based Multidisciplinary Study of Centenarians
Principal Investigator: Poon, L. W.
Sample description: Centenarians of North Georgia
Estimated number of centenarians: <500


Study title: Longevity Genes in Founder Populations
Principal Investigator: Shuldiner, A.R.
Sample description: Old Order Amish and Ashkenazi probands (age greater than 95 years) and their family members
Estimated number of centenarians: ~300


Study title: Genetic Studies of Successful Aging in the Amish
Principal Investigator: Scott, W.K.
Sample description: Amish adults aged 80 and older and their relatives.
Estimated number of centenarians: <200


Study title: Multicenter Study on Exceptional Survival in Families
Principal Investigator: Mayeux, R.
Sample description: Family history study of approximately 600 elderly residents, aged 95 years or older, residing in the New York, New Jersey, and Connecticut tri-state area.
Estimated number of centenarians: <200


Study title: Families of cohort survivors over 90
Principal Investigator: Newman, A.B.
Sample description: 400 individuals who have reached age 90 (participating in the Cardiovascular Health Study), their siblings and children
Estimated number of centenarians: <200


Corrections and additions are most welcome!

Steve Spindler

Greetings,

Recently a very clever and eloquent comment was posted at this blog. The author of this comment is Professor Steve Spindler. So I went to Medline to see his scientific publications and was pleased to find out that he has published 49 articles on aging and longevity studies in good scientific jounals. Here is a partial list of his most recent publications:

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1:	Dhahbi JM, Tsuchiya T, Kim HJ, Mote PL, Spindler SR.	Related Articles, Links
	Gene expression and physiologic responses of the heart to the initiation and withdrawal of caloric restriction. J Gerontol A Biol Sci Med Sci. 2006 Mar;61(3):218-31. PMID: 16567370 [PubMed - indexed for MEDLINE]

2:	Spindler SR.	Related Articles, Links
	Use of microarray biomarkers to identify longevity therapeutics. Aging Cell. 2006 Feb;5(1):39-50. PMID: 16441842 [PubMed - indexed for MEDLINE]

3:	Dhahbi JM, Mote PL, Fahy GM, Spindler SR.	Related Articles, Links
	Identification of potential caloric restriction mimetics by microarray profiling. Physiol Genomics. 2005 Nov 17;23(3):343-50. Epub 2005 Sep 27. PMID: 16189280 [PubMed - indexed for MEDLINE]

4:	Spindler SR.	Related Articles, Links
	Rapid and reversible induction of the longevity, anticancer and genomic effects of caloric restriction. Mech Ageing Dev. 2005 Sep;126(9):960-6. Review. PMID: 15927235 [PubMed - indexed for MEDLINE]

5:	Dhahbi JM, Kim HJ, Mote PL, Beaver RJ, Spindler SR.	Related Articles, Links
	Temporal linkage between the phenotypic and genomic responses to caloric restriction. Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5524-9. Epub 2004 Mar 25. PMID: 15044709 [PubMed - indexed for MEDLINE]

6:	Tsuchiya T, Dhahbi JM, Cui X, Mote PL, Bartke A, Spindler SR.	Related Articles, Links
	Additive regulation of hepatic gene expression by dwarfism and caloric restriction. Physiol Genomics. 2004 May 19;17(3):307-15. PMID: 15039484 [PubMed - indexed for MEDLINE]

7:	Dhahbi JM, Mote PL, Cao SX, Spindler SR.	Related Articles, Links
	Hepatic gene expression profiling of streptozotocin-induced diabetes. Diabetes Technol Ther. 2003;5(3):411-20. PMID: 12828825 [PubMed - indexed for MEDLINE]

8:	Spindler SR.	Related Articles, Links
	Reversing the negative genomic effects of aging with short-term calorie restriction. ScientificWorldJournal. 2001 Oct 12;1:544-6. Review. PMID: 12805847 [PubMed - indexed for MEDLINE]

9:	Weindruch R, Keenan KP, Carney JM, Fernandes G, Feuers RJ, Floyd RA, Halter JB, Ramsey JJ, Richardson A, Roth GS, Spindler SR.	Related Articles, Links
	Caloric restriction mimetics: metabolic interventions. J Gerontol A Biol Sci Med Sci. 2001 Mar;56 Spec No 1:20-33. Review. PMID: 12088209 [PubMed - indexed for MEDLINE]

10:	Spindler SR.	Related Articles, Links
	Calorie restriction enhances the expression of key metabolic enzymes associated with protein renewal during aging. Ann N Y Acad Sci. 2001 Apr;928:296-304. Review. PMID: 11795521 [PubMed - indexed for MEDLINE]

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It looks like the author is an expert in aging and longevity studies, and therefore his comments should be taken seriously.

Professor Steve Spindler also published book chapters in these scientific books:

Aging of the Organs and Systems
(Biology of Aging and its Modulation)
by Richard Aspinall


Dhahbi, J.M. and Spindler, S.R. Aging of the liver. In, Biology of Aging and its Modulation, Vol. 3: Aging of Organs and Systems , Aspinall, R., ed., Kluwer Academic Publisher, Dordrecht , The Netherlands , pp. 271-291 (2003).


Energy Metabolism and Lifespan Determination (Advances in Cell Aging and Gerontology)
by M.P. Mattson


Spindler, S.R. and Dhahbi, J.M. Protein Turnover, Energy Metabolism, Aging and Caloric Restriction. In, Energy Metabolism and Lifespan Determination: Advances in Cell Aging and Gerontology Vol. 14, Mattson, M.P., ed., Elsevier, Amsterdam , The Netherlands , pp. 69-86 (2003).