Wednesday, February 15, 2012

Press Release: Mortality Grossly Underestimated at Older Ages, New Study Finds

Dear Friend and Colleagues,

Feel free to disseminate widely our News Release (please see below) on important topic of human mortality and longevity, among reporters and journalists you may know, for their coverage of new research findings.

Full text of the original peer-reviewed article is available upon your request.

Thank you, and looking forward to hear from you,

Kind regards,


-- Leonid Gavrilov, Ph.D.
Fellow of the Gerontological Society of America
Center on Aging, NORC at the University of Chicago
Website: http://longevity-science.org/
Blog: http://longevity-science.blogspot.com/

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Press Release

Longevity Chances Grossly Overestimated, New Study Finds


The chances to reach extreme old age are much lower than previously thought, new research shows

Research just published by a team of demographers at the social science research organization NORC at the University of Chicago contradicts a long-held belief that the mortality rate of Americans flattens out above age 80.

It also explains why there are only half as many people in the U.S. age 100 and above than the Census Bureau predicted there would be as recently as six years ago.

The research is based on a new way of accurately measuring mortality of Americans who are 80 years of age and older, an issue that has proven remarkably elusive in the past. The work will be significant in arriving at more accurate cost projections for programs such as Social Security and Medicare, which are based in part on mortality rates.

The research, done by Leonid A. Gavrilov and Natalia S. Gavrilova, and published in the current edition of the North American Actuarial Journal, is based on highly accurate information about the date of birth and the date of death of more than nine million Americans born between 1875 and 1895. The data is publicly available in the Social Security Administration Death Master File (SSA DMF). “It is a remarkable resource that allowed us to build what is called an extinct birth cohort that corrects or explains a number of misunderstandings about the mortality rate of our oldest citizens,” said Leonid Gavrilov.

A stark example of the problem of estimating the number of people over 100 came recently when the U.S. Census Bureau revised sharply downward the number of living centenarians. Six years ago, the bureau predicted that by 2010 there would be 114,000 people age 100 or older. The actual number turned out to be 53,364. The projection was wrong by a factor of two.

The newly published paper, titled “Mortality Measurement at Advanced Ages: A Study of the Social Security Administration Death Master File,” explains the discrepancy and is likely to make a difference in the way mortality projections for the very old are done in the future.

The key finding is straightforward—the rate of mortality growth with age of the oldest Americans is the same as that for those who are younger. The research reveals that mortality deceleration, the long-held belief that the mortality rate flattens out above age 80, does not take place.

Anne Zissu, chair of the Department of Business NYC College of Technology/CUNY, said the research provides “an essential tool” for developing models on seniors’ financial assets.

Zissu said the research “will alter our financial approach to this valuation of mortality/longevity risk. Demographers and financiers need to work on this issue together, and their models must adapt to each other.”

The mortality rate for people between the ages of 30 and 80 follows what is called the Gompertz Law, named for its founder, Benjamin Gompertz, who observed in 1825 that a person’s risk of death in a given year doubles every eight years of age. It is a phenomenon that holds up across nations and over time and is an important part of the foundation of actuarial science.

For approximately 70 years, demographers have believed that above age 80 the Gompertz Law did not hold and that mortality rates flattened out. The work done by the Gavrilovs, a husband-and-wife team, reveals that the Gompertz Law holds at least through age 106, and probably higher, but the researchers say mortality data for those older than 106 is unreliable.

The Gavrilovs say the extinct birth cohort of people born between 1875 and 1895, which they built using the Social Security Administration Death Master File, reveals beyond question that the mortality rate of people in that cohort aligns with the Gompertz Law.

“It amazes me that the Gompertz model fits so well nearly 200 years after he proposed it. I like the approach of using extinct cohorts methods on SSA DMF data by month and the use of male-female ratios to test the quality of the data at advanced ages," said Tom Edwalds, Assistant Vice President, Mortality Research, for the Munich American Reassurance Company.

Prior estimates of the number of centenarians in the United States were made in less direct ways that were subject to error. They depended, for example, on people self-reporting their age in the U.S. Census, which is less reliable than having actual birth and death data.

Gavrilov and Gavrilova work at the Center on the Economics and Demography of Aging, one of the Academic Research Centers of NORC. The study is supported by the National Institute on Aging.

The Chicago Actuarial Association (CAA) has invited the authors to present their new findings at the CAA annual meeting in Chicago on March 13.

Full text of the original peer-reviewed published study is publicly available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269912/


About the Study Authors:

Leonid A. Gavrilov, Ph.D., is Principal Investigator of research project "Biodemography of Exceptional Longevity in the United States," awarded by 5-year grant from the National Institutes of Health, NIH. For more information, visit: http://www.norc.org/Experts/Pages/leonid-a-gavrilov.aspx . Contact e-mail: gavrilov(at)longevity-science.org

Natalia S. Gavrilova, Ph.D., is a Fellow of the Gerontological Society of America, and the author of over a hundred scientific publications. For more information, visit: http://longevity-science.org/CV-gavrilova.htm


About NORC:

NORC at the University of Chicago is an independent research organization headquartered in downtown Chicago with additional offices on the University of Chicago's campus and in the D.C. Metro area. NORC also supports a nationwide field staff as well as international research operations. With clients throughout the world, NORC collaborates with government agencies, foundations, educational institutions, nonprofit organizations, and businesses to provide data and analysis that support informed decision making in key areas including health, education, economics, crime, justice, energy, security, and the environment. NORC’s 70 years of leadership and experience in data collection, analysis, and dissemination—coupled with deep subject matter expertise—provides the foundation for effective solutions.

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Wednesday, March 25, 2009

An Unusual Source of Inspiration

See also:
-- 'Books Forum' blog
-- 'Health Studies' blog



Greetings,

I wonder what kinds of inspiration do you have in your life and research activities? Is it a great music, inspiring picture, absorbing book, scenic views, and/or a significant other?

Recently I have encountered a new unusual source of inspiration -- the NIH Summary Statement! Usually it is considered to be a bureaucratic document, which summarizes the results of a closed discussion of your research proposal by the panel of experts at the National Institute of Health, NIH. Typically this is a candid anonymous review, which is often painful to read to a scientist, the author of the reviewed proposal.

However, this time things are completely different. Our new research project was thoroughly evaluated by a review panel of 20 experts at NIH and the project was rated as being among the best 5 percent of all approved (scored) applications. Here is what they wrote (excerpts):
Summary Statement for Project "Biodemography of Exceptional Longevity in the United States"

Resume and Summary of Discussion:

"This ... application, by an eminent investigator, would use a variety of modeling methods to determine the social and biological factors linked to living to age 100. This is a major question for all fields of aging research. It is highly innovative application because it is going to examine a large relatively representative sample of those who reach 100. The approach is well-suited to the aims of the project. ... Strengths of the application include the significance of the aims, an innovative and carefully considered research design, a solid research team, supporting pilot research and well specified analytical methods. "


Critique 1:

Significance:
"This ... application, addresses early life covariates of extreme longevity in the U.S. This is a significant research topic with potential implications for health intervention in premature mortality and the proposed research could provide important confirmation, or refutation, of many theorized early life covariates of longevity."

Approach:
".... this is an innovative application utilizes genealogical, census, social-security, Internet and military data in a well crafted research design. "

Innovation:
"The application is an innovative one with a creative sample construction."

Investigators:
"This is an outstanding research team with an eminent Principal Investigator."

Overall Evaluation:
"This ... application, by an eminent investigator, would use a variety of modeling methods to study the effect of early life course circumstances on cases of extreme longevity in the United States. Strengths of the application include the significance of the aims, an innovative and carefully considered research design, a solid research team, supporting pilot research and well specified analytical methods."


Critique 2:

Significance:
"... a highly significant application. The project addresses important questions with an extremely innovative approach. Why some people live to 100 and others do not has been a focus of much NIA research, although much of this longevity research has been performed on other species. This application will provide increased understanding of how humans survive to very old ages using representative populations."

Approach:
"This application is harnessing the resources available on the Internet to address a very important scientific question. How do both social and biological factors affect the likelihood of living to very old age. The investigators have an unusually thorough command of both biological and the social literature appropriate to this question. The project will result in the examination of about 3,000 centenarians. Information on their early, adult, and later life is available. The combination of Census, Army, and Genealogical data is truly exciting. In addition, areal level data will be appended which has not been done before in analyses of long lives."

Innovation:
"The project is quite exciting because of the careful planning behind the proposed collection of available data in a novel way to address an important question which has not been well-addresses to date."

Investigators:
"This is an excellent team. The Principal Investigator, Leonid Gavrilov, is well-recognized as a biologist but he has made remarkable strides in becoming very multidisciplinary through the mechanism of a K award. The co Principal Investigator, Gavrilova, is also well-recognized as a biologist with many important publications related to the project. She, too, has undertaken recent training by getting a master's in computer science from the University of Chicago. This application builds on this strength in its approach to data collection."

Overall Evaluation:
"This is ... application with the major goals of determining social and biological factors linked to living to 100. This is a highly significant area because this is a major question for all fields of aging research. The approach is well-suited to the aims of the project. It is highly innovative application because it is going to examine a large relatively representative sample of those who reach 100. The major strengths of the application are its innovative use of publicly available data."


Critique 4:

Significance:
"This application will attempt to identify early life characteristics, which are associated with extreme long life. This is a highly significant issue. It has significant potential, depending upon the variables identified, to inform public health policy concerning longevity."

Innovation:
"This is an innovative study. It will assemble a unique data set concerning the early life characteristics of the elderly and a set of "controls". This will be a unique and useful resource for analysis of early life effects on mortality.

Investigators:
"This is an excellent research team. Gavrilov and Gavrilova are both productive and experienced researchers in the area of human aging."

Environment:
"The environment at the University of Chicago is excellent."

Overall Evaluation:
"This is ... application by an eminent research team that will assemble and analyze a unique data set concerning early life conditions on extreme longevity. In particular, the study will focus on socio economic factors and height and build. The analysis is well described and theoretically justified for the most part."


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So we have now a new awarded research project of certified high scientific merit, and we are open to collaboration on this new NIH Longevity Study !

Please feel free to post your comments and suggestions below by clicking here.


Key words:
Inspiration, NIH Summary Statement, Longevity, centenarians, biodemography, NIH, NIA, longevity genes, parental age, birth order, early-life living conditions, adult physical characteristics, reproductive history, Biodemography of Exceptional Longevity, Leonid Gavrilov, Natalia Gavrilova, Center on Aging, United States, National Institute on Aging, National Institutes of Health, Social Security Administration datasets, Census data, family reconstitutions, genealogies, military draft records, early-life childhood conditions.


Home:
Longevity Science Blog
and
Longevity Science: An Unusual Source of Inspiration
Shorter weblink:
http://tinyurl.com/d9mgga
and
http://tinyurl.com/NIH-approved

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Monday, February 23, 2009

Project Win Announcements - Biodemography of Exceptional Longevity

See also:
-- 'Books Forum' blog
-- 'Health Studies' blog



Greetings,

Here is an interesting announcement from the President's Office of the National Opinion Research Center, NORC, at the University of Chicago:

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From: President's Office
To: SP-All NORC Employees
Subject: Project Win Announcements - Biodemography of Exceptional Longevity


Biodemography of Exceptional Longevity


Senior Vice President and Director of the Academic Research Centers, is pleased to announce that NORC will study why people live to be 100 years or older.

The new study Biodemography of Exceptional Longevity in the United States is led co-investigators Leonid Gavrilov and Natalia Gavrilova, Research Associates in NORC’s Center on Aging. This husband-and-wife team has written extensively on extreme longevity. Their work has recently shown that longevity can be linked to a mother’s age at her child’s birth, birthplace within in the United States and family socioeconomic background.

The investigators will look at effects of early-life conditions, adult physical characteristics, and marriage and reproductive history on exceptional longevity. The new study takes advantage of U.S. Census and Social Security Administration data, genealogies, and military draft records. Researchers at the universities of Pennsylvania, Utah, and Wisconsin will also collaborate.

The project plan’s innovative use of data was called “exciting” by one of the reviewers at the sponsoring National Institute on Aging. Reviewers also commented favorably on other aspects, notably the strength of the research team and the overall significance of the project aims. The proposal was rated as being among the top 5 percent of all scored proposals reviewed by the NIH.

To read more about the Gavrilovs longevity studies, visit their scientific website at http://longevity-science.org/ ; also you can post your questions and comments at their discussion blog at: http://longevity-science.blogspot.com/

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Key words:
Longevity, centenarians, biodemography, NIH, NIA, longevity genes, parental age, birth order, early-life living conditions, adult physical characteristics, reproductive history, Biodemography of Exceptional Longevity, Leonid Gavrilov, Natalia Gavrilova, Center on Aging, United States, National Institute on Aging, National Institutes of Health, Social Security Administration datasets, Census data, family reconstitutions, genealogies, military draft records, early-life childhood conditions, National Opinion Research Center, NORC, University of Pennsylvania, University of Utah, University of Wisconsin-Madison.


Home:
Longevity Science Blog
and
Project Win Announcements - Biodemography of Exceptional Longevity
Shorter weblink:
http://tinyurl.com/bjawmu


Links to this post:

- Longevity study to be conducted by the National Opinion Research Center



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Monday, February 09, 2009

News Release: How Does One Reach 100? Chicago Researchers Will Study Determinants of Human Longevity

See also:
-- 'Books Forum' blog
-- 'Health Studies' blog




News Release from the Chicago University News Office:

How does one reach 100?
Research team will work toward identifying longevity determinants in NIH study

The University of Chicago Chronicle, February 5, 2009, Vol. 28 No. 9, page 3

http://chronicle.uchicago.edu/090205/study.shtml

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Full text:


How does one reach 100?
Research team will work toward identifying longevity determinants in NIH study


By William Harms
w-harms@uchicago.edu
News Office



The National Opinion Research Center will study why people live to be 100 years or older through a five-year grant from the National Institute on Aging.

Previous research has shown that a number of factors can lead to a person being two or three times more likely to live to extreme old age, said Leonid Gavrilov, Research Associate at the Center on Aging at NORC. The new project, “Biodemography of Exceptional Longevity in the United States,” will build on that work, he said. Gavrilov and his wife Natalia, also a Research Associate at NORC, are co-investigators on the project.

“This project will investigate why some people manage to survive to extreme old age and help identify the biological and social correlates of exceptional longevity,” Gavrilov explained. “We hope to find out the determinants of human longevity and to get insights into mechanisms and causes of long life.

“These are important issues, not only for demographic forecasts of human mortality and population aging, but also for improving our understanding of the fundamental mechanisms of human aging and longevity.”


Centenarians are one of the most rapidly growing segments of the U.S. population, according to the National Institute on Aging. The number of centenarians is growing at a rate of 4.1 percent per year; the numbers increased 51 percent between 1990 and 2000.

The new study will take advantage of U.S. Census and Social Security Administration data, genealogies and military draft records. Gavrilov will look at early-life conditions, adult physical characteristics, and marriage and reproductive history on exceptional longevity.

Gavrilov and his wife have written extensively on extreme longevity. Their work has recently shown that longevity can be linked to a mother’s age at her child’s birth, birthplace within in the United States and family socioeconomic background.

Babies born to mothers under age 25 were twice as likely to live to 100 years of age, compared to infants born to mothers 25 or older. Farmers tend to outlive others, and men who fathered more than four children by the time they were 30 also live longer, research found.

The potential impact on exceptional longevity of early-life living conditions shows that environmental and behavioral factors cannot be overlooked in longevity studies Gavrilov said.

“Even the search for ‘human longevity genes’ could be facilitated when powerful confounding effects of childhood environment are taken into account,” he said.

Gavrilov will collaborate with researchers at the University of Pennsylvania, the University of Utah and the University of Wisconsin, Madison.

To read more about the Gavrilovs’ longevity studies, visit http://longevity-science.org.

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Key words:
Longevity, centenarians, biodemography, NIH, NIA, longevity genes, parental age, birth order, early-life living conditions, adult physical characteristics, reproductive history, Biodemography of Exceptional Longevity, Leonid Gavrilov, Natalia Gavrilova, Center on Aging, United States, National Institute on Aging, National Institutes of Health, Social Security Administration datasets, Census data, family reconstitutions, genealogies, military draft records, early-life childhood conditions, National Opinion Research Center, University of Pennsylvania, University of Utah, University of Wisconsin-Madison.


Home:
Longevity Science Blog
and
News Release: How Does One Reach 100? Chicago Researchers Will Study Determinants of Human Longevity
Shorter weblink:
http://tinyurl.com/db4kem



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Thursday, January 08, 2009

New NIH Longevity Study

See also:
-- 'Books Forum' blog
-- 'Health Studies' blog




Greetings,

Here are some really good news for the New Year 2009:

The US National Institutes of Health (NIH) have awarded us with a new 5-year research grant to study the mechanisms of human longevity!

Moreover, when this new research project was thoroughly evaluated by a review panel of 20 experts at NIH, the project was rated as being among the best 5 percent of all approved (scored) applications.

The details of this new award are now publicly available through CRISP (Computer Retrieval of Information on Scientific Projects), a searchable database of federally funded biomedical research projects, by clicking here, or through this weblink: http://tinyurl.com/9th6jx

Here are some slightly edited excerpts:

Project Title:
Biodemography of Exceptional Longevity in the United States


Abstract:

This project proposes to investigate why some people manage to survive to extreme old age (100+ years) and what are the biological and social correlates of exceptional longevity. These are important issues not only for demographic forecasts of human mortality and population aging, and the policy implications on health-care and pension expenditures, but also for improving our understanding of the fundamental mechanisms of human aging and longevity.

The project will take advantage of the ongoing revolution in information technology for human longevity studies to examine the determinants of exceptional survival both on individual and population levels, using a rich variety of the U.S. data sources available through the Internet, including Social Security Administration datasets, Census data, family reconstitutions and validated genealogies, and military draft records.

Recent findings from the Principal Investigator's pilot study of U.S. centenarians, funded by the Chicago Center on Aging and the Society of Actuaries, suggest that differences in chances of exceptional survival as large as two or three times can be linked to early-life circumstances, such as mother's age at person's birth, person's birth order, birth place within the United States, and family socioeconomic background.

The plasticity of exceptional longevity in response to early-life living conditions indicates that environmental and behavioral factors cannot be overlooked in longevity studies. Even the search for "human longevity genes" could be facilitated when powerful confounding effects of childhood environment are taken into account. This project therefore proposes to explore the effects of early-life living conditions, adult physical characteristics, marriage, and reproductive history on exceptional longevity, and will test a number of related biomedical and social hypotheses.

The project is designed as an interdisciplinary study of exceptional human longevity. To contribute to the research infrastructure for subsequent longevity studies world-wide, the Principal Investigator will also develop a database with integrated, matched information on longevity predictor variables, and make it available to the research community on the Internet. The project will allow establishing scientific collaboration of the Center on Aging, NORC/University of Chicago with other researchers to study the biodemography of exceptional longevity in an interdisciplinary context.


Public Health Relevance:

Demographic aging of the United States has profound public health implications, particularly because centenarians (people living to 100 and beyond) represent one of the most rapidly growing segments of the U.S. population. This study advances understanding of biological, social and environmental factors that favor survival to extreme old ages, including early-life childhood conditions, and it has implications for public health policy, population forecasting and health planning.

So we have now an approved research project of certified high scientific merit, and we are open to collaboration on this new NIH Longevity Study !

Please post your comments and suggestions below by clicking here.


Key words:
Longevity, centenarians, biodemography, NIH, NIA, longevity genes, parental age, birth order, early-life living conditions, adult physical characteristics, reproductive history, Biodemography of Exceptional Longevity, Leonid Gavrilov, Natalia Gavrilova, Center on Aging, United States, National Institute on Aging, National Institutes of Health, Social Security Administration datasets, Census data, family reconstitutions, genealogies, military draft records, early-life childhood conditions.


Home:
Longevity Science Blog
and
New NIH Longevity Study
Shorter weblink:
http://tinyurl.com/8uk8ew


Links to this post:

- NIH awards grant to longevity science blog writer


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