Scientific Meeting in Moscow - “From Homo sapiens to Homo sapiens liberatus”

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-- 'Books Forum' blog
-- 'Health Studies' blog


Dear Friends!

We are pleased to share with you the program of international scientific conference on aging and longevity, which was held at Moscow State University recently (with our participation and presentation there)

You can see the Power-Point-Presentation of our study here:

"Comparative analysis of parameters of human ontogenesis and senescence"

http://longevity-science.org/Ontogenesis-Senescence.ppt

Any comments and suggestions are most welcome!


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Workshop “From Homo sapiens to Homo sapiens liberatus”

25 May

9.15-9.45 Registration, coffee

9.45-12.00 Chairman, D.B. Zorov

9.45-10.00 V.P. Skulachev. Introductory remarks

10.00-10.45 V.P. Skulachev and M.V. Skulachev The present state of the art of SkQ Megaproject

10.45-11.00 Discussion

11.00-11.15 B. Cannon. Effects of SkQ1 on progeric “Mutator mice” (report 1)

11.15-11.30 Discussion

11.30-11.45 J. Nedergaard. Effects of SkQ1 on progeric “Mutator mice” (report 2)

11.45-12.00 Discussion

12.00-12.30 Coffee break

12.30-14.30 Chairmen, B. Cannon, V.I. Kapelko

12.30-12.45 D.B. Zorov. Effects of SkQs on kidney and brain ischemia/reperfusion injuries.

12.45-13.00 Discussion

13.00-13.15 B.V. Chernyak. SkQ1 accelerates dermal wound healing and arrests the age-dependent decline of this process

13.15-13.30 Discussion

13.30-13.45 N.G. Kolosova. Effects of SkQ on cataract and retinopathies in OXYS rats.

13.45-14.00 Discussion

14.00-14.15 A.A. Zamyatnin. Clinical trials of the SkQ1 drops in treatment of “dry eye”

14.15014.30 Discussion

14.30-15.45 Lunch

15.45-17.45 Chairmen, J. Nedergaard, E.I. Rogaev

15.45-16.00 V.N. Anisimov. Effects of SkQ on SHR and HER-2 mice.

16.00-16.15 Discussion

16.15-16.30 F.F. Severin. Two mechanisms of antioxidant activity of SkQs.

16.30-16.45 Discussion

16.45-17.00 D.A. Cherepanov. Possible role of the Complex III bound cardiolipin dimer in initiation of mitochondrial lipid peroxidation

17.00-17.15 Discussion

17.15-17.30 S. A. Nedospasov. Unexpected features in mice with mutant cytochrome c.

17.30-17.45 Discussion

17.45-18.15 Coffee break

18.15-18.30 R. Zinovkin. How counterproductive programs could escape elimination by natural selection?

18.30-18.45 Discussion

18.45-19.00 V. Gorbunova. Naked mole-rat, a rodent lacking the senescence program, in comparison with his senescing relatives.

19.00-19.15 Discussion

19.45-20.15 Chairmen, G. Libertini, L. Gavrilov

19.15-19.30 A. Siluanov. Naked mole-rat, a cancer-resistant animal.

19.30-19.45 Discussion

19.45-20.00 H.S. Saunders. Programmed vs stochastic aging mechanisms.

20.00-20.15 Discussion

26 May

9.30-12.00 Chairmen, J. Mitteldorf, S.A. Nedospasov

9.30-9.45 K. Lewis. Examples of counterproductive genetic programs in prokaryotes.

9.45-10.00 Discussion

10.00-10.15 N. Gavrilova. Comparative analysis of parameters of human ontogenesis and senescence.

10.15-10.30 Discussion

10.30-10.45 G. Libertini. Aging in wild nature.

10.45-11.00 Discussion

11.00-11.15 T. Goldsmith. Biological functions of aging.

11.15-11.30 Discussion

11.30-12.00 Coffee break

12.00-14.00 Chairmen, T. Goldsmith, B.V. Chernyak

12.00-12.15 J. Mitteldorf. Evolvability, a necessary component of biological evolution

12.15-12.30 Discussion

12.30-12.45 C.J. Hauser. Appearance of mitochondrial DNA and formyl methionine in the blood induces programmed death of organism, resembling septic shock.

12.45-13.00 Discussion

13.00-13.30 General discussion

13.30-13.45 A.G. Ryazanov. An enzyme which shortens the lifespan

13.45-14.00 Discussion

14.00-15.30 Lunch

15.30-16.45 Discussion on establishment of the Homo sapiens liberatus (HSL) movement. Chairman V.P. Skulachev

16.45-17.00 Concluding remarks

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Abstract of our presentation:

Comparative analysis of parameters of human ontogenesis and senescence

Natalia S. Gavrilova and Leonid A. Gavrilov
Center on Aging, NORC and The University of Chicago

The idea of this study is to compare standard deviations for parameters, which are known to be determined by the developmental program (such as ages of sexual maturity) with variation of characteristics related to aging (such as menopause and death).

One of the arguments used by the opponents of programmed aging is a too high variation in individual lifespans compared to the observed variation of programmed events (such as the age of sexual maturation). The main objective of this study is to test the validity of this argument.

Presentation provides the first results on this topic of scientific studies. In particular, data available in the scientific literature on variability of ages at sexual maturation (menarche), menopause and death are compared to results obtained from the nationally representative survey of adult population of the United States (MIDUS) as well as official life table data.

It is shown that standard deviations for age at onset of menarche are about 10 times smaller than standard deviations for ages of death. Such a difference corresponds well to a difference in mean values of ages when menarche and death occur. Thus, the adjusted variability (coefficient of variation) for age at death is of a similar order of magnitude as that for ages at onset of menarche.

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Comments and suggestions are welcome!

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Scientific Meeting in Moscow - “From Homo sapiens to Homo sapiens liberatus”
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News from the 'Science for Life Extension' Foundation: Aging -- not a destiny!

See also:
-- 'Books Forum' blog
-- 'Health Studies' blog


Greetings,

Recently the 'Science for Life Extension' Foundation has published an interesting news announcement at its website here:

http://www.scienceagainstaging.com/News/news_07.html

For your convenience this Russian text is translated into English below:

Aging -- not a destiny!

Charity evening meeting, April 17, 2009, Moscow.
At this charity event the presentation was made, describing the work of the 'Science for Life Extension' Foundation and its objectives.


Aging -- not a destiny! This was the title of a charitable meeting of the Foundation 'Science for Life Extension', which took place in a comfortable informal environment of the Tsurtsum Cafe at the Winery place (Moscow, Russia). It is this environment, which provided an opportunity for guests to absorb the vast amount of knowledge about human aging, and about the opportunities offered, and to be offered by science to combat it.

The purpose of the meeting - to allow guests (which were people of many different professions - politicians, businessmen, designers, representatives of the various foundations) to learn as much about aging as possible, and to learn that aging could be defeated in the foreseeable future. Knowledge leads to action, and therefore the second goal of the Foundation 'Science for Life Extension' was to get as many supporters and partners as possible.

The chairman of the Board of Trustees of the Foundation, Michael Batin shared with guests his plans, and the most important of them - the development of an integrated interdisciplinary program 'Science against aging', which the Foundation is being developing for a year already, inviting contributions from leading researchers in Russia and abroad. Among the guests of the meeting were the Foundation's experts, internationally recognized scientists: Leonid Gavrilov and Natalia Gavrilova, Alexei Olovnikov, Vladimir Skulachev and Maxim Skulachev.

The program is a set of research tasks for different scientific disciplines in the study of mechanisms of aging and life extension. This work unprecedented in world science has already been highly evaluated by international scientific community. The second working version of the program was published in February 2009, the next version will be released in May and it will be presented at the International Congress of Gerontology and Geriatrics (IAGG) in Paris.

Still this is only the beginning of the work, which will transform the program into a comprehensive document that would serve as both a guide and a tool not only for scientists but also for politicians, policy makers, and national governments, to ensure that the fight against aging follows a coherent strategic plan. Michael Batin announced the budget expenses, which are necessary to complete the first phase of program creation: ten million Russian rubles, of which three million - are the funds of the Foundation itself and seven million - the requested support from investors.

To see short version of the Presentation click here.

Download the full version of the Presentation
in Microsoft PowerPoint 2007 format (6,5 Mb)

See Photos from the Charity meeting

Also you are cordially invited to participate in discussion of this new 'Science Against Aging' Research Plan:

http://longevity-science.org/SCIENCE_AGAINST_AGING_RESEARCH_PLAN.pdf
Shorter weblink:
http://tinyurl.com/df2kvg

To read comments on this topic and to participate in further discussions by posting your own thoughts and suggestions, you are welcome to click here.


Key words:
Science Against Aging, Science for Life Extension, 'Science for Life Extension' Foundation,Aging - not a destiny!, Michael Batin, Leonid Gavrilov, Natalia Gavrilova, Alexei Olovnikov, Vladimir Skulachev, Maxim Skulachev, Program 'Science against aging', International Congress of Gerontology and Geriatrics (IAGG), ageing, aging, anti-aging, Life Extension, Longevity

Home:
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and
News from the 'Science for Life Extension'Foundation: Aging -- not a destiny!
Shorter weblink:
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Meeting Photo:

Chairman of the Board of Trustees of the 'Science for Life Extension' Foundation, Michael Batin, shared his ambitious plans with the guests (see below).






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International Conference on Aging & Longevity Studies

Greetings,

I am pleased to announce the upcoming International Conference on Aging & Longevity Studies, which brings together researchers from Russia and the United States at Moscow State University, this month.

This unusual, brain-storming Conference is organized by Professor Vladimir Skulachev , the member of the Russian Academy of Sciences, and Director of the A. N. Belozersky Institute of Physico-Chemical Biology at Moscow State University, Moscow.

Note that the term "phenoptosis" used in this conference program is a code word for "programmed death," and that the title of the conference (see below) may cause an excitement in the transhumanism movement. Frankly speaking, the conference is centered around this 'crazy' scientific idea:

Is aging an atavistic program that can be 'simply' switched off?

Scientific Conference
"From Homo sapiens to Homo sapiens discatenatus"

August 27-28, 2007, Moscow State University, Moscow, Russia
Vorobievy Hills, Laboratory Korpus B, room 221


August 27
A. Introductory Lecture
Chairman: A.M. Olovnikov
10.00-11.00 a.m. -- Skulachev Vladimir P.
Are there genetic programs, beneficial for survival, diversity and expansion of genome, but deleterious for individual?
11.00-11.30 a.m. -- Discussion

B. Acute phenoptosis

1. 11.30-12.00 a.m. -- Lewis Kim
Department of Biology, Northeastern University, Boston, USA
Phenoptosis in Bacteria

12.00-12.30 a.m. -- Break

Chairman: K. Lewis
2. 12.30-13.00 -- Severin F.
Phenoptosis in Yeast

3. 13.00-13.30 -- Moshkin M.
Phenoptosis in Animals: death of males of marsupial mice after reproduction and other examples.

4. 13.30-14.00 -- Zorov D.
Anti-phenoptotic activity of SkQ in kidney ischemia and stroke.

14.00-16.00 -- Break


C. Aging as slow phenoptosis
Chairman: V.N. Anisimov
1. 16.00-16.30 -- Olovnikov A.M.
Is it possible to create a long living mouse? Genome and Paragenome. Paragenome -- the material substrate for a lifespan program.

2. 16.30-17.00 -- Golub B.
Winter hibernation and the rate of individual development.

3. 17.00-17.30 -- Gavrilova Natalia S.
Center on Aging, NORC at the University of Chicago, USA
Hibernation, Aging and Longevity

4. 17.30-18.00 -- Ryazanov Alexey G.
Department of Pharmacology, University of Medicine and Dentistry of New Jersey - Robert Wood Johnson Medical School, Piscataway, USA.
eEF2-kinase: aging accelerating enzyme.

5. 18.00-18.30 -- Khrapko Konstantin
Harvard Medical School, Boston, USA
Mitochondrial hypotheses of aging.


August 28
D. Pro and contra
Chairman: Chernyak B.V.

1. 10.00-10.30 -- Gavrilov Leonid A.
Center on Aging, NORC at the University of Chicago, USA
Aging: Reliability theory and the concept of phenoptosis

2. 10.30-11.00 -- Popov I.
The benefits and costs of evolution.

3. 11.00-11.30 -- Ryazanov Alexey G.
Department of Pharmacology, University of Medicine and Dentistry of New Jersey - Robert Wood Johnson Medical School, Piscataway, USA.
Aging and apoptosis.

4. 11.30-12.00 -- Chumakov P.
Anti- and pro- oxidant properties of the P53 protein and its role in aging.

12.00 -12.30 -- Break

Chairman: Ryazanov A. G.
5. 12.30-13.00 -- Khohlov A.N.
Pro and contra for the programmed aging hypothesis.

6. 13.00-13.30 -- Anisimov V.N.
Hot topics of modern gerontology.

7. 13.30-14.00 -- Kondrashov Alexey S.
Life Sciences Institute, University of Michigan, Ann Arbor, USA
(kondrash(at)umich.edu)
Could evolution create genetic programs deleterious for individual?

8. 14.00-15.00. General Discussion


The original text of the Conference Program in Russian language is available here.

To read comments on this Conference, and to post your own thoughts, click here


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and
International Conference on Aging & Longevity Studies
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